NDLI: Cell-division-cycle defects associated with fission yeast pre-mRNA splicing mutants

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Current Genetics : Volume 34, Issue 2, August 1998

Current Genetics : Volume 34, Issue 1, July 1998

Current Genetics : Volume 33

Current Genetics : Volume 32

Current Genetics : Volume 31

Cell-division-cycle defects associated with fission yeast pre-mRNA splicing mutants

Content Provider	Springer Nature Link
Author	Potashkin, Judith Kim, Daemyung Fons, Mark Humphrey, Tim Frendewey, David
Copyright Year	1998
Abstract	We have isolated six new pre-mRNA splicing mutants (prp) from a collection of temperature-sensitive (ts–) Schizosaccharomyces pombe strains. The prp mutants are defective in the splicing of both messenger RNA and U6 small nuclear RNA precursors. A single recessive mutation is responsible for both the ts – growth and the splicing phenotypes in each of the prp mutants. The six prp mutations are unlinked and fall into separate complementation groups. Two are allelic with the previously described prp3 and prp4 mutations; the remaining four define the new alleles prp5-1, prp6-1, prp7-1, and prp9-1. The six mutants exhibit three splicing phenotypes: accumulation of unspliced precursor at the restrictive but not at the permissive temperature; accumulation of unspliced precursor at both the permissive and restrictive temperatures; and accumulation of unspliced precursor, the intron-exon lariat intermediate, and the intron lariat final product. In addition to their aberrant splicing phenotypes, the prp5-1 and prp6-1 mutants express classical cell-division-cycle defects, while prp7-1 exhibits an unusual hyphal morphology. These results suggest a connection between pre-mRNA splicing and the control of cell division in fission yeast.
Starting Page	153
Ending Page	163
Page Count	11
File Format	PDF
ISSN	01728083
Journal	Current Genetics
Volume Number	34
Issue Number	3
e-ISSN	14320983
Language	English
Publisher	Springer-Verlag
Publisher Date	1998-09-16
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine

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