NDLI: Intramolecular cross-overs generate deleted mitochondrial DNA molecules in Podospora anserina

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Current Genetics : Volume 31, Issue 1, January 1997

Intramolecular cross-overs generate deleted mitochondrial DNA molecules in Podospora anserina

Content Provider	Springer Nature Link
Author	Jamet Vierny, C. Boulay, Jocelyne Briand, Jean François
Copyright Year	1997
Abstract	The unavoidable senescence process that limits the vegetative growth of Podospora anserina is always associated with an accumulation of various classes of circular, tandemly arranged, defective mitochondrial DNA molecules (senDNAs). The monomers of the senDNAs belonging to the so-called β class share a common core, but differ in both their length and termini. To understand the mechanism leading to their formation, we have determined the junction sequence of 36 senDNA β monomers present in various senescent cultures. In most cases, we observe that: (1) short direct repeats precisely bound the senDNA β termini and (2) one copy of the repeats is retained in the senDNA sequence. Moreover, PCR analysis of the mitochondrial DNA of some of the senescent cultures, has allowed us to detect another genome which is exactly lacking the sequence of the senDNA β found in the culture. These results demonstrate that an intramolecular unequal cross-over occurring between short direct repeats can generate deleted mtDNA molecules in P. anserina. In addition, the polymorphism displayed by one pair of repeats allows us to establish that this cross-over may be associated with a short conversion tract spanning a few (about 15) nucleotides.
Starting Page	162
Ending Page	170
Page Count	9
File Format	PDF
ISSN	01728083
Journal	Current Genetics
Volume Number	31
Issue Number	2
e-ISSN	14320983
Language	English
Publisher	Springer-Verlag
Publisher Date	1997-02-28
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine

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Intramolecular cross-overs generate deleted mitochondrial DNA molecules in Podospora anserina

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