NDLI: Biological evaluation of poly-l-lactic acid composite containing bioactive glass

Content Provider	Springer Nature Link
Author	Zhou, Zhihua Zhou, Jianan Yi, Qingfeng Liu, Lihua Zhao, Yanmin Nie, Huidong Liu, Xiaoping Zou, Jianpeng Chen, Lianglong
Copyright Year	2010
Abstract	Biodegradable and biocompatible materials are the basis for medical application. As an initial step for developing bone internal fixation materials, the biological evaluation of poly-l-lactic acid/bioactive glass (PLLA/BG) composite in vitro and in vivo, including the hemolysis test, pyrogen test, acute systemic toxicity test, genetic toxicity test, anaphylaxis test, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) test, direct cell culture and in vivo implant experiment, was performed. The results indicated that PLLA/BG composite showed no acute systemic toxicity, genetic toxicity, anaphylaxis reaction, and pyrogen reaction, and the hemolysis ratio was 0.39%. MTT assay indicated that no cytotoxic effect was observed for the PLLA/BG composite, and in addition, a significant increase in cellular activity compared to the negative control group was found. Excellent adhesion between fibroblast and PLLA/BG material was observed, the fibroblasts cultured on the PLLA/BG composite substrates revealed a higher proliferation and differentiation rate than those on the pure PLLA substrates. In vivo implant experiment showed that the PLLA/BG composite could maintain the mechanical properties during the course of fracture therapy, and the malleolar fracture of rabbits was healed in 8 weeks on the whole. Therefore, PLLA/BG composites have a promising biological response as a potential implant material.
Starting Page	411
Ending Page	423
Page Count	13
File Format	PDF
ISSN	01700839
Journal	Polymer Bulletin
Volume Number	65
Issue Number	4
e-ISSN	14362449
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-03-14
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Poly-l-lactic acid Bioactive glass Composite Biological evaluation Cytotoxicity Internal fixation Physical Chemistry Characterization and Evaluation of Materials Soft and Granular Matter, Complex Fluids and Microfluidics Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry Condensed Matter Physics Polymers and Plastics

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