NDLI: Preparation and evaluation of O-carboxymethyl chitosan/cyclodextrin nanoparticles as hydrophobic drug delivery carriers

Content Provider	Springer Nature Link
Author	Ji, Jingou Hao, Shilei Liu, Weiqi Zhang, Jingfen Wu, Danjun Xu, Yi
Copyright Year	2011
Abstract	In present study, novel composite nanocarriers comprised of O-carboxymethyl chitosan/β-cyclodextrin (O-CMC/β-CD) nanoparticles (NPS) were prepared and used to improve the bioavailability of hydrophobic drugs. Ibuprofen (IBU) was selected as a model drug and chitosan/β-CD (CS/β-CD) NPS were also prepared as control. The prepared NPS were characterized by FT-IR spectroscopy and X-ray diffraction. IBU entrapment of up to 93.25 ± 2.89% was obtained as determined by UV spectrophotometer. The NPS were spherical in shape with average particle sizes of 166 nm. The in vitro release studies were performed in simulated gastric medium (pH 1.2) and simulated intestinal medium (pH 6.8). The release rate of IBU from the O-CMC/β-CD NPS was slower than CS/β-CD NPS in simulated gastric medium. However, the converse tendency was observed in simulated intestinal medium. These results suggested that O-CMC/β-CD NPS were more suitable for the oral delivery of hydrophobic drugs compared with the CS/β-CD NPS.
Starting Page	1201
Ending Page	1213
Page Count	13
File Format	PDF
ISSN	01700839
Journal	Polymer Bulletin
Volume Number	67
Issue Number	7
e-ISSN	14362449
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-01-20
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Chitosan O-Carboxymethyl Cyclodextrin Ibuprofen Bioavailability Soft and Granular Matter, Complex Fluids and Microfluidics Polymer Sciences Physical Chemistry Characterization and Evaluation of Materials
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry Condensed Matter Physics Polymers and Plastics

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