NDLI: Long-term release of chlorhexidine from dental adhesive resin system using human serum albumin nanoparticles

Content Provider	Springer Nature Link
Author	Kim, Hyun Jin Kwon, Tae Yub Kim, Kyo Han Kwon, Soon Taek Cho, Dae Hyun Son, Jun Sik
Copyright Year	2014
Abstract	A functional dental adhesive resin system with antimicrobial properties was developed using human serum albumin (HSA) nanoparticles as the drug delivery carrier. HSA nanoparticles loaded with chlorhexidine (CHX) diacetate, a model antimicrobial drug, were prepared using a desolvation technique. The resulting CHX-loaded HSA nanoparticles were incorporated into a commercial methyl methacrylate (MMA)-based resin. The size of the nanoparticles ranged 50–300 nm, and the nanoparticles were dispersed homogeneously in the resin matrix. The CHX-loaded HSA nanoparticles showed an early release burst of ~20 % of the total CHX by day 5, followed by the sustained release of the remaining CHX over the next 20 days. In contrast, the resin matrix containing the HSA nanoparticles showed a sustained release of CHX without an early release burst in a 4-week immersion study. In the agar diffusion test, the resin matrix incorporating the CHX-loaded HAS nanoparticles showed a larger growth inhibition zone against Streptococcus mutans than the resin matrix alone, indicating that this delivery platform potently imparts antibacterial activity to the resins. These results also suggest that CHX, which inhibits the growth of oral bacteria, can be incorporated efficiently into the MMA-based resin matrix using HSA nanoparticles.
Starting Page	875
Ending Page	886
Page Count	12
File Format	PDF
ISSN	01700839
Journal	Polymer Bulletin
Volume Number	71
Issue Number	4
e-ISSN	14362449
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-02-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Dental adhesive resin system Antibacterial effect Chlorhexidine Nanoparticle Human serum albumin Polymer Sciences Soft and Granular Matter, Complex Fluids and Microfluidics Characterization and Evaluation of Materials Physical Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry Condensed Matter Physics Polymers and Plastics

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