NDLI: Inter-polymer complex microspheres of chitosan and cellulose acetate phthalate for oral delivery of 5-fluorouracil

Content Provider	Springer Nature Link
Author	Thakker, Shalin P. Rokhade, Ajit P. Abbigerimath, Shivayya S. Iliger, Sudhir R. Kulkarni, Venkatarao H. More, Uttam A. Aminabhavi, Tejraj M.
Copyright Year	2014
Abstract	Inter-polymer complexes (IPCs) of chitosan (CS) and cellulose acetate phthalate (CAP) have been prepared to develop spherical microspheres by a novel emulsion-solvent evaporation technique. The microspheres were used for the oral delivery of 5-fluorouracil (5-FU), an antimetabolite and antineoplastic agent, whose release time was extended up to 12 h. Formulations were prepared by varying the concentrations of CS, CAP and 5-FU. FTIR confirmed the formation of IPC, indicating no chemical interactions of 5-FU with the polymer matrix. Scanning electron microscopy suggested spherical shape of the microspheres with smooth surfaces. Average particle size measured by optical microscopy varied between 2.7 and 5.5 μm. Differential scanning calorimetry showed amorphous dispersion of 5-FU particles into the IPC matrix. Encapsulation efficiency as estimated by UV was dependent on polymer composition with the highest value of 96 %. Water uptake by the IPC microspheres was higher at higher concentration of CS in the matrix. In vitro drug release performed in pH 1.2 and pH 7.4 buffer media showed a dependence on compositions of CS, CAP and drug loading. Molar mass between cross-links (M c) and cross-link density (d x ) values of the polymer matrix calculated from swelling data indicated the formation of a dense matrix between CS and CAP; the matrix was able to control the release of 5-FU. The in vitro release data have been fitted to empirical equations to understand the nature of drug release mechanism.
Starting Page	2113
Ending Page	2131
Page Count	19
File Format	PDF
ISSN	01700839
Journal	Polymer Bulletin
Volume Number	71
Issue Number	8
e-ISSN	14362449
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-05-10
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Chitosan Cellulose acetate phthalate 5-Fluorouracil Controlled release Oral delivery Empirical equations Polymer Sciences Soft and Granular Matter, Complex Fluids and Microfluidics Characterization and Evaluation of Materials Physical Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry Condensed Matter Physics Polymers and Plastics

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