NDLI: Synthesis, characterization and in vitro drug release property of amino acid end-capped aliphatic polycarbonates

Content Provider	Springer Nature Link
Author	Zhou, Yu Xie, Xin Zeng, Jun Jie Ge, Jun Chen, Hong Xiang
Copyright Year	2013
Abstract	A series of amino acid end-capped aliphatic polycarbonates (CV-PDTC)s was synthesized via ring-opening polymerization of 2,2-dimethyl trimethylene carbonate initiated by N-carbobenzyloxy-l-valine without metallic catalyst. The chemical structure of CV-PDTC was verified by Fourier transform infrared spectra, nuclear magnetic resonance spectra (1H NMR) and gel permeation chromatography. The molecular weight of CV-PDTC could be adjusted by varying reaction condition. The thermal behavior of resultant polycarbonates was measured by differential scanning calorimetry, the result indicated that the crystalline property was related to the structure. The drug release results demonstrated that CV-PDTC had a good sustained-release effect for drug, and that the release behavior was controlled by a diffusion–degradation mechanism.
Starting Page	673
Ending Page	683
Page Count	11
File Format	PDF
ISSN	01700839
Journal	Polymer Bulletin
Volume Number	71
Issue Number	3
e-ISSN	14362449
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-12-20
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Aliphatic polycarbonate Amino acid Ring-opening polymerization Drug delivery carrier Polymer Sciences Soft and Granular Matter, Complex Fluids and Microfluidics Characterization and Evaluation of Materials Physical Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry Condensed Matter Physics Polymers and Plastics

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