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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ouyang, Chunping Liu, Qian Zhao, Shunxin Ma, Guilei Zhang, Zhengpu Song, Cunxian |
| Copyright Year | 2011 |
| Abstract | The star-shaped poly (lactide-co-glycolide) (PLGA) was synthesized via the ring-opening polymerization of d,l-lactide and glycolide, with pentaerythritol as a multifunctional initiator and stannous 2-ethyl hexanoate as a catalyst. The structures of these polymers were characterized by 13C-NMR spectroscopy, while the molecular weight and polydispersity index (PDI) were determined by gel permeation chromatography (GPC). The glass transition temperature (T g) of copolymer was determined by differential scanning calorimetry (DSC). Bovine serum albumin (BSA) loaded microspheres were fabricated using star-shaped PLGA by a W/O/W double emulsion solvent evaporation method. The results of characterization demonstrated that the particle size of the PLGA microspheres were about 80–150 μm, the maximum loading capacity and encapsulation efficiency of BSA-loaded microspheres were 67.51 μg/(mg microspheres) and 78.39%, respectively, which were better than linear PLGA. The in vitro release profiles of BSA in phosphate buffer saline (PBS) lasted for 37 h. Drug release profiles can be affected by polymer molecular weight and the ratio of polymer to drug. The maximum release percentage was 80%. |
| Starting Page | 27 |
| Ending Page | 36 |
| Page Count | 10 |
| File Format | |
| ISSN | 01700839 |
| Journal | Polymer Bulletin |
| Volume Number | 68 |
| Issue Number | 1 |
| e-ISSN | 14362449 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2011-06-10 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | BSA Drug-loaded microspheres Encapsulation efficiency Loading capacity Star-shaped PLGA Physical Chemistry Polymer Sciences Soft and Granular Matter, Complex Fluids and Microfluidics Characterization and Evaluation of Materials |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Materials Chemistry Condensed Matter Physics Polymers and Plastics |
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