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| Content Provider | Springer Nature Link |
|---|---|
| Author | Chen, Xiuqiong Yan, Huiqiong Sun, Wei Feng, Yuhong Li, Jiacheng Lin, Qiang Shi, Zaifeng Wang, Xianghui |
| Copyright Year | 2015 |
| Abstract | As a kind of novel hydrophobic drug carrier materials, the drug-loaded nanofibers were successfully fabricated using amphiphilic alginate derivative (AAD) and poly (vinyl alcohol) (PVA) by electrospinning method. The AAD was synthesized by amide linkage attachment of octylamine onto the carboxylic group of alginate, which was characterized by the means of elemental analysis, FT-IR spectrometer, 1H NMR spectrometer and fluorescence measurement. Experimental results showed the amidation of alginate was successful, in which the degree of modification was 0.27 and the critical aggregation concentration in 0.15 mol/L aqueous NaCl solution was 0.43 mg/mL. The octyl groups of AAD could effectively make alginate chains flexible and enhance chain entanglements through the hydrophobic interactions between octyl groups. In contrast to sodium alginate (SA)/PVA blend solutions, AAD/PVA blend solutions showed more excellent electrospinnability. Additionally, the different volume ratios of SA or AAD to PVA played an important role in the formation and morphology of the electrospun blend nanofibers. Although the amidation of alginate could not fundamentally alter the spinnability of alginate, the content of alginate in the blend nanofibers was appropriately increased. The new generated drug-loaded AAD/PVA (20/80) blend nanofibers exhibited relatively continuous and uniform nanofibers with the average diameter of 191.72 nm. Compared to the drug-loaded SA/PVA (20/80) blend nanofibers, the drug-loaded AAD/PVA (20/80) blend nanofibers presented a sustained release performance with the slow release of about 76 % λ-cyhalothrin during the initial period of 10 h. |
| Starting Page | 3097 |
| Ending Page | 3117 |
| Page Count | 21 |
| File Format | |
| ISSN | 01700839 |
| Journal | Polymer Bulletin |
| Volume Number | 72 |
| Issue Number | 12 |
| e-ISSN | 14362449 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2015-08-05 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Alginate Amphiphilic alginate derivative The amidation Poly (vinyl alcohol) Electrospinning Blend nanofibers Polymer Sciences Soft and Granular Matter, Complex Fluids and Microfluidics Characterization and Evaluation of Materials Physical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Materials Chemistry Condensed Matter Physics Polymers and Plastics |
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