NDLI: Selective sweeps for recessive alleles and for other modes of dominance

Content Provider	Springer Nature Link
Author	Rudolf, J. Hermisson, J. Pfaffelhuber, P. Ewing, G.
Copyright Year	2010
Abstract	A selective sweep describes the reduction of linked genetic variation due to strong positive selection. If s is the fitness advantage of a homozygote for the beneficial allele and h its dominance coefficient, it is usually assumed that h = 1/2, i.e. the beneficial allele is co-dominant. We complement existing theory for selective sweeps by assuming that h is any value in [0, 1]. We show that genetic diversity patterns under selective sweeps with strength s and dominance 0 < h < 1 are similar to co-dominant sweeps with selection strength 2hs. Moreover, we focus on the case h = 0 of a completely recessive beneficial allele. We find that the length of the sweep, i.e. the time from occurrence until fixation of the beneficial allele, is of the order of $${\sqrt{N/s}}$$ generations, if N is the population size. Simulations as well as our results show that genetic diversity patterns in the recessive case h = 0 greatly differ from all other cases.
Ending Page	431
Page Count	33
Starting Page	399
File Format	PDF
ISSN	03036812
e-ISSN	14321416
Journal	Journal of Mathematical Biology
Issue Number	3
Volume Number	63
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-11-13
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Beneficial mutation Genealogy Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) Mathematical and Computational Biology Recessive allele Interacting random processes; statistical mechanics type models; percolation theory Selective sweep Applications of Mathematics Genetic hitchhiking Problems related to evolution
Content Type	Text
Resource Type	Article
Subject	Applied Mathematics Agricultural and Biological Sciences Modeling and Simulation

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