NDLI: Spontaneous White Sectored-Mutants in Streptomyces hygroscopicus 111-81: Characterization and Antibiotic Productivity

Content Provider	Springer Nature Link
Author	Gesheva, Victoria
Copyright Year	2008
Abstract	Spontaneous white mutants from sectors of Streptomyces hygroscopicus 111-81 were isolated. The comparison of morphological, cultural, and biochemical properties of the mutants and ancestor showed the differences in colors of aerial, substrate mycelia, and sporulation. Changes in resistance to antibiotics and sensitivity to lysozyme indicated alterations in cell walls and cell membranes of the mutants. They showed antifungal activity close to that of the parent strain on fermentation medium FM2, with unchanged component composition of the AK-111-81 antibiotic complex. The cells of spontaneous white mutants are characterized with electron-transparent structures, vacuoles, aggregation of ribosomes, intrahyphal growth, and lack of multiple cell septa, which was established by transmission electron microscopy. The appearance of white sectored-mutants in S. hygroscopicus 111-81 is connected with exhausting of nutrients causing the substrate limitation and is a stress response to starvation.
Starting Page	133
Ending Page	138
Page Count	6
File Format	PDF
ISSN	03438651
Journal	Current Microbiology
Volume Number	57
Issue Number	2
e-ISSN	14320991
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-04-30
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biotechnology Microbiology
Content Type	Text
Resource Type	Article
Subject	Medicine Microbiology Applied Microbiology and Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Optimization of the Production Medium for Biosynthesis of Antifungal Antibiotic Ak-111-81 by Phosphate-Deregulated Mutant of Streptomyces hygroscopicus

Impact of Carboxymethylcellulose on Morphology and Antibiotic Production by Streptomyces hygroscopicus

Identification and characterization of antifungal active substances of Streptomyces hygroscopicus BS-112

Enhanced rapamycin production in Streptomyces hygroscopicus by integrative expression of aveR, a LAL family transcriptional regulator

Identification of the biosynthetic gene cluster for the antibiotic polyketide L-155,175 in Streptomyces hygroscopicus

Identification of AHBA Biosynthetic Genes Related to Geldanamycin Biosynthesis in Streptomyces hygroscopicus 17997

Insights into the metabolic mechanism of rapamycin overproduction in the shikimate-resistant Streptomyces hygroscopicus strain UV-II using comparative metabolomics

A High-Throughput Method for Screening of Rapamycin-Producing Strains of Streptomyces hygroscopicus by Cultivation in 96-Well Microtiter Plates

Chemometric Approach to Prediction of Antibacterial Agent Production by Streptomyces hygroscopicus

Spontaneous White Sectored-Mutants in Streptomyces hygroscopicus 111-81: Characterization and Antibiotic Productivity

Similar Documents

Optimization of the Production Medium for Biosynthesis of Antifungal Antibiotic Ak-111-81 by Phosphate-Deregulated Mutant of Streptomyces hygroscopicus

Impact of Carboxymethylcellulose on Morphology and Antibiotic Production by Streptomyces hygroscopicus

Identification and characterization of antifungal active substances of Streptomyces hygroscopicus BS-112

Enhanced rapamycin production in Streptomyces hygroscopicus by integrative expression of aveR, a LAL family transcriptional regulator

Identification of the biosynthetic gene cluster for the antibiotic polyketide L-155,175 in Streptomyces hygroscopicus

Identification of AHBA Biosynthetic Genes Related to Geldanamycin Biosynthesis in Streptomyces hygroscopicus 17997

Insights into the metabolic mechanism of rapamycin overproduction in the shikimate-resistant Streptomyces hygroscopicus strain UV-II using comparative metabolomics

A High-Throughput Method for Screening of Rapamycin-Producing Strains of Streptomyces hygroscopicus by Cultivation in 96-Well Microtiter Plates

Chemometric Approach to Prediction of Antibacterial Agent Production by Streptomyces hygroscopicus

Spontaneous White Sectored-Mutants in Streptomyces hygroscopicus 111-81: Characterization and Antibiotic Productivity