NDLI: Influenza pathogenicity during pregnancy in women and animal models

Content Provider	Springer Nature Link
Author	Riel, Debby Mittrücker, Hans Willi Engels, Geraldine Klingel, Karin Markert, Udo R. Gabriel, Gülsah
Copyright Year	2016
Abstract	Pregnant women are at the highest risk to develop severe and even fatal influenza. The high vulnerability of women against influenza A virus infections during pregnancy was repeatedly highlighted during influenza pandemics including the pandemic of this century. In 2009, mortality rates were particularly high among otherwise healthy pregnant women. However, our current understanding of the molecular mechanisms involved in severe disease development during pregnancy is still very limited. In this review, we summarize the knowledge on the clinical observations in influenza A virus-infected pregnant women. In addition, knowledge obtained from few existing experimental infections in pregnant animal models is discussed. Since clinical data do not provide in-depth information on the pathogenesis of severe influenza during pregnancy, adequate animal models are urgently required that mimic clinical findings. Studies in pregnant animal models will allow the dissection of involved molecular disease pathways that are key to improve patient management and care.
Starting Page	719
Ending Page	726
Page Count	8
File Format	PDF
ISSN	18632297
Journal	Springer Seminars in Immunopathology
Volume Number	38
Issue Number	6
e-ISSN	18632300
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-07-07
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Influenza Pregnancy Pathogenesis Animal models Immunology Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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