NDLI: Signals that influence T follicular helper cell differentiation and function

Please wait, while we are loading the content...

Springer Seminars in Immunopathology : Volume 39

Springer Seminars in Immunopathology : Volume 38

Springer Seminars in Immunopathology : Volume 37

Springer Seminars in Immunopathology : Volume 36

Springer Seminars in Immunopathology : Volume 35

Springer Seminars in Immunopathology : Volume 34

Springer Seminars in Immunopathology : Volume 33

Springer Seminars in Immunopathology : Volume 32

Springer Seminars in Immunopathology : Volume 32, Issue 4, December 2010

Springer Seminars in Immunopathology : Volume 32, Issue 3, September 2010

Springer Seminars in Immunopathology : Volume 32, Issue 2, June 2010

T-cell signaling and immunopathologies

Regulatory T cells: roles of T cell receptor for their development and function

ZAP70: a master regulator of adaptive immunity

Lymphoproliferative disorders involving T helper effector cells with defective LAT signalosomes

Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases

Cbl-b in T-cell activation

Foxp3 positive regulatory T cells: a functional regulation by the E3 ubiquitin ligase Itch

SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions

Immunopathologies linked to integrin signalling

Signals that influence T follicular helper cell differentiation and function

Exploring the roles of CD8+ T lymphocytes in the pathogenesis of autoimmune demyelination

Springer Seminars in Immunopathology : Volume 32, Issue 1, March 2010

Springer Seminars in Immunopathology : Volume 31

Springer Seminars in Immunopathology : Volume 30

Springer Seminars in Immunopathology : Volume 29

Springer Seminars in Immunopathology : Volume 28

Springer Seminars in Immunopathology : Volume 27

Springer Seminars in Immunopathology : Volume 26

Springer Seminars in Immunopathology : Volume 25

Springer Seminars in Immunopathology : Volume 24

Springer Seminars in Immunopathology : Volume 23

Springer Seminars in Immunopathology : Volume 22

Springer Seminars in Immunopathology : Volume 21

Springer Seminars in Immunopathology : Volume 20

Springer Seminars in Immunopathology : Volume 19

Springer Seminars in Immunopathology : Volume 18

Signals that influence T follicular helper cell differentiation and function

Content Provider	Springer Nature Link
Author	Linterman, Michelle A. Vinuesa, Carola G.
Copyright Year	2010
Abstract	Follicular helper T cells have recently emerged as a separate CD4+ T helper lineage specialised in provision of help to B cells. They develop independently from Th1, Th2 and Th17 cells and are critical for humoral immunity, including the generation of long-lived and high affinity plasma cells and memory cells crucial for long-term protection against infections. A stepwise differentiation programme has emerged in which T cell receptor (TCR) signalling strength, CD28-mediated costimulation, B cell-derived inducible costimulator ligand signals, induction of c-maf and actions of cytokines, including interleukin (IL)-6 and IL-21, lead to upregulation of the transcriptional repressor B cell lymphoma 6 (Bcl-6) that drives T follicular helper (Tfh) cell differentiation. Bcl-6 turns on a repression programme that targets Blimp-1, transcriptional regulators of other helper lineages and microRNAs. Their concerted actions modulate expression of chemokine receptors, surface molecules and cytokines critical for follicular homing and B cell helper functions. Here, we review the nature of Tfh cells providing help to B cells during the two phases of B cell activation that occur in the outer T zone and, for some B cells, in germinal centres (GC). Recent insights into the signalling events that drive terminal differentiation of Tfh cells critical for selecting somatically mutated GC B cells and the consequences of Tfh dysregulation for immunodeficiency and autoimmune pathology are discussed.
Starting Page	183
Ending Page	196
Page Count	14
File Format	PDF
ISSN	18632297
Journal	Springer Seminars in Immunopathology
Volume Number	32
Issue Number	2
e-ISSN	18632300
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-01-27
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Bcl-6 T follicular helper cells (Tfh) TCR signalling CD28 Costimulation ICOS IL-21 SAP (Sh2d1a) Internal Medicine Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Regulators of Tfh Cell Differentiation

T Follicular Helper Cell Subsets and the Associated Cytokine IL-21 in the Pathogenesis and Therapy of Asthma

Enhanced IL-6/phosphorylated STAT3 signaling is related to the imbalance of circulating T follicular helper/T follicular regulatory cells in patients with rheumatoid arthritis

T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship

Case Report: IL-21 and Bcl-6 Regulate the Proliferation and Secretion of Tfh and Tfr Cells in the Intestinal Germinal Center of Patients With Inflammatory Bowel Disease

Molecular Control of Follicular Helper T cell Development and Differentiation

Role of TRAFs in Signaling Pathways Controlling T Follicular Helper Cell Differentiation and T Cell-Dependent Antibody Responses

Abnormal Shift in B Memory Cell Profile Is Associated With the Expansion of Circulating T Follicular Helper Cells via ICOS Signaling During Acute HIV-1 Infection

Transcriptome and TCR Repertoire Measurements of CXCR3+ T Follicular Helper Cells Within HIV-Infected Human Lymph Nodes

Signals that influence T follicular helper cell differentiation and function

Similar Documents

Regulators of Tfh Cell Differentiation

T Follicular Helper Cell Subsets and the Associated Cytokine IL-21 in the Pathogenesis and Therapy of Asthma

Enhanced IL-6/phosphorylated STAT3 signaling is related to the imbalance of circulating T follicular helper/T follicular regulatory cells in patients with rheumatoid arthritis

T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship

Case Report: IL-21 and Bcl-6 Regulate the Proliferation and Secretion of Tfh and Tfr Cells in the Intestinal Germinal Center of Patients With Inflammatory Bowel Disease

Molecular Control of Follicular Helper T cell Development and Differentiation

Role of TRAFs in Signaling Pathways Controlling T Follicular Helper Cell Differentiation and T Cell-Dependent Antibody Responses

Abnormal Shift in B Memory Cell Profile Is Associated With the Expansion of Circulating T Follicular Helper Cells via ICOS Signaling During Acute HIV-1 Infection

Transcriptome and TCR Repertoire Measurements of CXCR3+ T Follicular Helper Cells Within HIV-Infected Human Lymph Nodes

Signals that influence T follicular helper cell differentiation and function