NDLI: Pathogenesis of implant-associated infection: the role of the host

Content Provider	Springer Nature Link
Author	Zimmerli, Werner Sendi, Parham
Copyright Year	2011
Abstract	Implanted devices are mainly used to improve impaired function or to replace missing anatomic structures. They are made of synthetic material or devitalized biological structures. In contrast to vital transplants, they are not rejected by the body. However, the host reacts against these foreign bodies, a process which can be designated as biocompatibility. The interaction of the device with adjacent granulocytes and complement not only induces various degrees of inflammation but also impairs local microbial clearance. Foreign surfaces are a preferred target for bacterial adherence. While adhering bacteria are highly resistant to the bactericidal activity of phagocytes, they are also resistant to most antimicrobial agents. Certain bacteria may reside within host cells, and hence, evade host defense mechanisms by persisting intracellularly around implants. Nanotechnology minimizes clotting activation and bacterial adhesion by intravascular devices. Furthermore, surface coating with appropriate substances favorably influences biocompatibility as well as susceptibility to infection. In the future, “Microsystems Technology” deployed as intelligent device may decrease the risk of implant failure due to infection.
Starting Page	295
Ending Page	306
Page Count	12
File Format	PDF
ISSN	18632297
Journal	Springer Seminars in Immunopathology
Volume Number	33
Issue Number	3
e-ISSN	18632300
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-05-21
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biocompatibility Implant-associated infection Neointima Biofilm Acquired immune defect Immunology Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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