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| Content Provider | Springer Nature Link |
|---|---|
| Author | Brizić, Ilija Lenac Roviš, Tihana Krmpotić, Astrid Jonjić, Stipan |
| Copyright Year | 2014 |
| Abstract | Natural killer (NK) cells play an important role in virus control during infection. Many viruses have developed mechanisms for subversion of NK cell responses. Murine cytomegalovirus (MCMV) is exceptionally successful in avoiding NK cell control. Here, we summarize the major MCMV evasion mechanisms targeting NK cell functions and their role in viral pathogenesis. The mechanisms by which NK cells regulate CD8+ T cell response, particularly with respect to the role of NK cell receptors recognizing viral antigens, are discussed. In addition, we discuss the role of NK cell receptors in generation and maintenance of memory NK cells. Final part of this review illustrates how the NK cell response and its viral regulation can be exploited in designing recombinant viral vectors able to induce robust and protective CD8+ T cell response. |
| Starting Page | 641 |
| Ending Page | 650 |
| Page Count | 10 |
| File Format | |
| ISSN | 18632297 |
| Journal | Springer Seminars in Immunopathology |
| Volume Number | 36 |
| Issue Number | 6 |
| e-ISSN | 18632300 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2014-08-21 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | MCMV NK cell receptors Immune evasion Memory NK cells CMV vaccine vector NK cell - T cell crosstalk Immunology Internal Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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