NDLI: Immunopathology of lupus nephritis

Content Provider	Springer Nature Link
Author	Anders, Hans Joachim Fogo, Agnes B.
Copyright Year	2013
Abstract	When patients with systemic lupus erythematosus (SLE) present with urinary abnormalities, a renal biopsy is usually needed to rule out or confirm lupus nephritis. Renal biopsy is also needed to define the type of renal manifestation as different entities are associated with different outcomes; hence, renal biopsy results shape lupus management. But why does lupus nephritis come in different shapes? Why do patients with SLE often show change over time in class of lupus nephritis or have mixed forms? How does autoimmunity in SLE evolve? Why does loss of tolerance against nuclear antigens preferentially affect the kidney? Why are immune complex deposits in different glomerular compartments associated with different outcomes? What determines crescent formation in lupus? In this review, we discuss these questions by linking the latest information on lupus pathogenesis into the context of the different classes of lupus nephritis. This should help the basic scientist, the pathologist, and the clinician to gain a more conceptual view on the immunopathology of lupus nephritis.
Starting Page	443
Ending Page	459
Page Count	17
File Format	PDF
ISSN	18632297
Journal	Springer Seminars in Immunopathology
Volume Number	36
Issue Number	4
e-ISSN	18632300
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-01-09
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Immune complex Belimumab Interferon Systemic lupus erythematosus Chronic kidney disease Glomerulonephritis Immunology Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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