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  1. Springer Seminars in Immunopathology
  2. Springer Seminars in Immunopathology : Volume 39
  3. Springer Seminars in Immunopathology : Volume 39, Issue 1, January 2017
  4. TH9 cells in anti-tumor immunity
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Springer Seminars in Immunopathology : Volume 39
Springer Seminars in Immunopathology : Volume 39, Issue 3, April 2017
Springer Seminars in Immunopathology : Volume 39, Issue 2, February 2017
Springer Seminars in Immunopathology : Volume 39, Issue 1, January 2017
Th9 cells in immunity and immunopathological diseases
Discovery and initial characterization of Th9 cells: the early years
The transcription factor network in Th9 cells
TNF superfamily cytokines in the promotion of Th9 differentiation and immunopathology
IL-9 and Th9 in parasite immunity
TH9 cells in anti-tumor immunity
TH9 cells in skin disorders
Th9 and other IL-9-producing cells in allergic asthma
IL-9-producing cells in the development of IgE-mediated food allergy
Th9 cells in the pathogenesis of EAE and multiple sclerosis
Th9 cells in inflammatory bowel diseases
Springer Seminars in Immunopathology : Volume 38
Springer Seminars in Immunopathology : Volume 37
Springer Seminars in Immunopathology : Volume 36
Springer Seminars in Immunopathology : Volume 35
Springer Seminars in Immunopathology : Volume 34
Springer Seminars in Immunopathology : Volume 33
Springer Seminars in Immunopathology : Volume 32
Springer Seminars in Immunopathology : Volume 31
Springer Seminars in Immunopathology : Volume 30
Springer Seminars in Immunopathology : Volume 29
Springer Seminars in Immunopathology : Volume 28
Springer Seminars in Immunopathology : Volume 27
Springer Seminars in Immunopathology : Volume 26
Springer Seminars in Immunopathology : Volume 25
Springer Seminars in Immunopathology : Volume 24
Springer Seminars in Immunopathology : Volume 23
Springer Seminars in Immunopathology : Volume 22
Springer Seminars in Immunopathology : Volume 21
Springer Seminars in Immunopathology : Volume 20
Springer Seminars in Immunopathology : Volume 19
Springer Seminars in Immunopathology : Volume 18

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TH9 cells in anti-tumor immunity

Content Provider Springer Nature Link
Author Rivera Vargas, Thaiz Humblin, Etienne Végran, Frédérique Ghiringhelli, François Apetoh, Lionel
Copyright Year 2016
Abstract IL-9 was initially identified as a T cell growth factor with a potential oncogenic activity. Accordingly, IL-9 drives tumor growth in most hematological cancers. However, the links between IL-9 and cancer progression have been recently revisited following the discovery of TH9 cells. TH9 cells, which have been characterized in 2008 as a proinflammatory CD4 T cell subset that promotes protection against parasites and drives tissue inflammation in colitis, actually harbor potent IL-9-dependent anti-cancer properties in solid tumors and especially melanoma. While the molecular mechanisms underlying these observations are still being investigated, TH9 cells were demonstrated to activate both innate and adaptive immune responses, thereby favoring anti-cancer immunity and tumor elimination. Human TH9 cells have also been identified in cancer tissues, but their functions remain elusive. The present review aims to discuss the anti-cancer potential of TH9 cells and their possible clinical relevance for cancer immunotherapy.
Starting Page 39
Ending Page 46
Page Count 8
File Format PDF
ISSN 18632297
Journal Springer Seminars in Immunopathology
Volume Number 39
Issue Number 1
e-ISSN 18632300
Language English
Publisher Springer Berlin Heidelberg
Publisher Date 2016-11-10
Publisher Place Berlin, Heidelberg
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Adaptive immunity CD4 T cells Gene transcription Cancer Innate immunity Immunomodulation Immunology Internal Medicine
Content Type Text
Resource Type Article
Subject Immunology and Allergy Immunology
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