NDLI: Modification of accessory molecule signaling

Content Provider	Springer Nature Link
Author	Crow, Mary K.
Copyright Year	2006
Abstract	The concept of costimulation, the requirement for an independent accessory cellular activation signal that supplements the signal delivered to a lymphocyte by antigen, has been a focal point of progress in understanding the regulation of the immune system. While considerable attention has been directed to new developments related to the activation of cells of the innate immune system through Toll-like receptors, resulting in the production of soluble mediators, augmented expression of cell surface costimulatory molecules on antigen-presenting cells is arguably the most significant early outcome of immune system activation. It is those cell surface molecules that provide the essential afferent costimulatory signals to T cells of the adaptive immune response. Once fully activated, T cells express their own cell surface accessory molecules that permit those T cells to instruct interacting B cells, macrophages, and dendritic cells to further implement an effective immune response. Significantly for patients with autoimmune diseases, the manipulation of costimulatory signals represents a rational and effective approach to modulating the chronic immune system activation that characterizes those diseases. Further elucidation of the complexities of members of the accessory molecule families and their functions should lead to an ever greater capacity for therapeutic modulation of the immune response in autoimmune and inflammatory diseases.
Starting Page	409
Ending Page	424
Page Count	16
File Format	PDF
ISSN	03444325
Journal	Springer Seminars in Immunopathology
Volume Number	27
Issue Number	4
e-ISSN	14322196
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-05-16
Publisher Place	Berlin, Heidelberg
Access Restriction	Subscribed
Subject Keyword	Internal Medicine Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology

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