NDLI: Combination DNA plus protein HIV vaccines

Content Provider	Springer Nature Link
Author	Lu, Shan
Copyright Year	2006
Abstract	A major challenge in developing an HIV vaccine is to identify immunogens and delivery methods that will elicit balanced humoral and cell mediate immunities against primary isolates of HIV with diverse sequence variations. Since the discovery of using protein coding nucleic acids (mainly DNA but also possible RNA) as a means of immunization in the early 1990s, there has been rapid progress in the creative use of this novel approach for the development of HIV vaccines. Although the initial impetus of using DNA immunization was for the induction of strong cell-mediated immunity, recent studies have greatly expanded our understanding on the potential role of DNA immunization to elicit improved quality of antibody responses. This function is particularly important to the development of HIV vaccines due to the inability of almost every previous attempt to develop broadly reactive neutralizing antibodies against primary HIV-1 isolates. Similar to the efforts of developing cell mediated immunity by using a DNA prime plus viral vector boost approach, the best antibody responses with DNA immunization were achieved when a protein boost component was included as part of the immunization schedule. Current experience has suggested that a combination DNA plus protein vaccination strategy is able to utilize the benefits of DNA and protein vaccines to effectively induce both cell-mediated immunity and antibody responses against invading organisms.
Starting Page	255
Ending Page	265
Page Count	11
File Format	PDF
ISSN	03444325
Journal	Springer Seminars in Immunopathology
Volume Number	28
Issue Number	3
e-ISSN	14322196
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-09-21
Publisher Place	Berlin, Heidelberg
Access Restriction	Subscribed
Subject Keyword	HIV Vaccine DNA Protein Internal Medicine Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology

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