NDLI: The NLR network and the immunological disease continuum of adaptive and innate immune-mediated inflammation against self

Content Provider	Springer Nature Link
Author	McGonagle, Dennis Savic, Sinisa McDermott, Michael F.
Copyright Year	2007
Abstract	The nucleotide-binding domain, leucine-rich repeat containing family (NLR) network has provided pivotal genetic and molecular insights into diseases that were hitherto regarded as autoimmune. The NLR-related disorders include rare monogenic autoinflammatory diseases collectively termed cryopyrin-associated periodic syndromes, Crohn’s disease which is a common polygenic disease and also an association at the mechanistic level with gout and pseudogout. Unlike the classical autoimmune diseases where disease immunopathogenesis is played out primarily in the primary and secondary lymphoid organs, the immunopathogenesis of the NLR-related disorders is played out in the tissues where inflammation arises. As the genetic mutations or molecular cascades associated with the NLR-related disorders have a widespread cellular distribution, it has been somewhat enigmatic why these disorders attack certain territories, but not others. This implies that tissue-specific factors in the target organs themselves contribute to disease expression. Such examples include the high abundance of NOD2 expressing cells in the part of the gut most typically afflicted by Crohn’s disease and the preferential deposition of crystals in the joints to where inflammation localises in gout and pseudogout. The NLR network is associated principally with increases in TNF or IL-1 production, both of which are key players in innate immunity. Therefore, the NLR network identifies at the genetic and molecular level a robust paradigm for innate immune activation against self. This tissue-specific-factor-associated inflammation is the diametric opposite of classical autoimmunity. Of note, the MHC class-I-associated diseases including psoriasis (HLA-Cw6) and ankylosing spondylitis (HLA-B27) show striking clinical overlaps with Crohn’s disease and also some rare monogenic diseases. Thus, the NLR innate immune pathway allows the full spectrum of inflammation against self to be viewed along an immunological disease continuum with autoantibody-associated disease at one end, innate immune diseases at the other and MHC class-1-related disorders as an intermediate.
Starting Page	303
Ending Page	313
Page Count	11
File Format	PDF
ISSN	18632297
Journal	Springer Seminars in Immunopathology
Volume Number	29
Issue Number	3
e-ISSN	18632300
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-09-06
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Internal Medicine Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum

TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system

“TRP inflammation” relationship in cardiovascular system

Innate and adaptive immune responses against Staphylococcus aureus skin infections

Neutrophils in innate and adaptive immunity

Innate and adaptive immunity in atherosclerosis

The Critical Role of PARPs in Regulating Innate Immune Responses

Immunological mechanisms in the pathogenesis of diabetic retinopathy

Regulatory roles of mast cells in immune responses

The NLR network and the immunological disease continuum of adaptive and innate immune-mediated inflammation against self

Similar Documents

Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum

TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system

“TRP inflammation” relationship in cardiovascular system

Innate and adaptive immune responses against Staphylococcus aureus skin infections

Neutrophils in innate and adaptive immunity

Innate and adaptive immunity in atherosclerosis

The Critical Role of PARPs in Regulating Innate Immune Responses

Immunological mechanisms in the pathogenesis of diabetic retinopathy

Regulatory roles of mast cells in immune responses

The NLR network and the immunological disease continuum of adaptive and innate immune-mediated inflammation against self