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Springer Seminars in Immunopathology : Volume 39

Springer Seminars in Immunopathology : Volume 38

Springer Seminars in Immunopathology : Volume 37

Springer Seminars in Immunopathology : Volume 37, Issue 6, November 2015

Role of astrocytes and microglia in central nervous system inflammation

Glial regulation of the blood-brain barrier in health and disease

Do not judge a cell by its cover—diversity of CNS resident, adjoining and infiltrating myeloid cells in inflammation

β-amyloid, microglia, and the inflammasome in Alzheimer’s disease

Differential roles of resident microglia and infiltrating monocytes in murine CNS autoimmunity

Control of autoimmune CNS inflammation by astrocytes

Regulation of human glia by multiple sclerosis disease modifying therapies

Springer Seminars in Immunopathology : Volume 37, Issue 5, September 2015

Springer Seminars in Immunopathology : Volume 37, Issue 4, July 2015

Springer Seminars in Immunopathology : Volume 37, Issue 3, May 2015

Springer Seminars in Immunopathology : Volume 37, Issue 2, March 2015

Springer Seminars in Immunopathology : Volume 37, Issue 1, January 2015

Springer Seminars in Immunopathology : Volume 36

Springer Seminars in Immunopathology : Volume 35

Springer Seminars in Immunopathology : Volume 34

Springer Seminars in Immunopathology : Volume 33

Springer Seminars in Immunopathology : Volume 32

Springer Seminars in Immunopathology : Volume 31

Springer Seminars in Immunopathology : Volume 30

Springer Seminars in Immunopathology : Volume 29

Springer Seminars in Immunopathology : Volume 28

Springer Seminars in Immunopathology : Volume 27

Springer Seminars in Immunopathology : Volume 26

Springer Seminars in Immunopathology : Volume 25

Springer Seminars in Immunopathology : Volume 24

Springer Seminars in Immunopathology : Volume 23

Springer Seminars in Immunopathology : Volume 22

Springer Seminars in Immunopathology : Volume 21

Springer Seminars in Immunopathology : Volume 20

Springer Seminars in Immunopathology : Volume 19

Springer Seminars in Immunopathology : Volume 18

Regulation of human glia by multiple sclerosis disease modifying therapies

Content Provider	Springer Nature Link
Author	Healy, Luke M. Michell Robinson, Mackenzie A. Antel, Jack P.
Copyright Year	2015
Abstract	This review focuses on the effects of the agents currently approved (or in late clinical trials) as therapies for multiple sclerosis (MS) on the glial cell populations of the central nervous system (CNS). These are comprised of astrocytes, microglia, and oligodendrocytes (OLs), and their progenitors (OPCs). Although the efficacy of these agents is to date established only for the relapsing component of the disease and linked to effects on the systemic immune system, each has been examined with regard to effects on the CNS compartment. The impact of therapies on glia would include modulating these cells immune reactivity, which is considered to underlie the tissue injury process in MS and to any subsequent repair process. As reviewed, these agents can exert their effects either indirectly by modulating the constituents of the systemic immune system or directly depending on their capacity to traverse the blood brain barrier (BBB). Most available data has been derived from administration of these agents in animal models or application to glial cells in vitro. The challenge remains of translating these observations into effective means to impact on the progressive course of disease and reverse existent disabilities.
Starting Page	639
Ending Page	649
Page Count	11
File Format	PDF
ISSN	18632297
Journal	Springer Seminars in Immunopathology
Volume Number	37
Issue Number	6
e-ISSN	18632300
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-08-11
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Immunology Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Inhibition of Human Neutrophil Functions In Vitro by Multiple Sclerosis Disease-Modifying Therapies

Identification of a gene expression signature in peripheral blood of multiple sclerosis patients treated with disease-modifying therapies.

Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies

Central nervous system demyelinating diseases: glial cells at the hub of pathology

Disease-modifying therapies for multiple sclerosis (Published 27 November 2018)

The TCR Repertoire Reconstitution in Multiple Sclerosis: Comparing One-Shot and Continuous Immunosuppressive Therapies

Effects of Three Months Fingolimod Therapy on Heart Rate

Disease modifying therapies for relapsing multiple sclerosis (Published 22 August 2016)

Cost of disease-modifying therapies for multiple sclerosis.

Regulation of human glia by multiple sclerosis disease modifying therapies

Similar Documents

Inhibition of Human Neutrophil Functions In Vitro by Multiple Sclerosis Disease-Modifying Therapies

Identification of a gene expression signature in peripheral blood of multiple sclerosis patients treated with disease-modifying therapies.

Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies

Central nervous system demyelinating diseases: glial cells at the hub of pathology

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Cost of disease-modifying therapies for multiple sclerosis.

Regulation of human glia by multiple sclerosis disease modifying therapies