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  1. Springer Seminars in Immunopathology
  2. Springer Seminars in Immunopathology : Volume 30
  3. Springer Seminars in Immunopathology : Volume 30, Issue 3, July 2008
  4. Nox enzymes in immune cells
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Springer Seminars in Immunopathology : Volume 39
Springer Seminars in Immunopathology : Volume 38
Springer Seminars in Immunopathology : Volume 37
Springer Seminars in Immunopathology : Volume 36
Springer Seminars in Immunopathology : Volume 35
Springer Seminars in Immunopathology : Volume 34
Springer Seminars in Immunopathology : Volume 33
Springer Seminars in Immunopathology : Volume 32
Springer Seminars in Immunopathology : Volume 31
Springer Seminars in Immunopathology : Volume 30
Springer Seminars in Immunopathology : Volume 30, Issue 4, December 2008
Springer Seminars in Immunopathology : Volume 30, Issue 3, July 2008
NOX enzymes in immuno-inflammatory pathologies
Nox enzymes in immune cells
Genetics and immunopathology of chronic granulomatous disease
Role of Nox2 in elimination of microorganisms
Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase
The NADPH oxidase NOX2 plays a role in periodontal pathologies
Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane
NOX enzymes and Toll-like receptor signaling
NOX enzymes and diabetic complications
Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract
Oxidative stress and the pathogenesis of scleroderma: the Murrell’s hypothesis revisited
NOX enzymes as novel targets for drug development
Remarks on the article Genetics and immunopathology of chronic granulomatous disease by Marie José Stasia and Xing Jun Li
Reply to the remarks by Joachim Roesler on the article Genetics and immunopathology of chronic granulomatous disease
Springer Seminars in Immunopathology : Volume 30, Issue 2, April 2008
Springer Seminars in Immunopathology : Volume 30, Issue 1, February 2008
Springer Seminars in Immunopathology : Volume 29
Springer Seminars in Immunopathology : Volume 28
Springer Seminars in Immunopathology : Volume 27
Springer Seminars in Immunopathology : Volume 26
Springer Seminars in Immunopathology : Volume 25
Springer Seminars in Immunopathology : Volume 24
Springer Seminars in Immunopathology : Volume 23
Springer Seminars in Immunopathology : Volume 22
Springer Seminars in Immunopathology : Volume 21
Springer Seminars in Immunopathology : Volume 20
Springer Seminars in Immunopathology : Volume 19
Springer Seminars in Immunopathology : Volume 18

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Nox enzymes in immune cells

Content Provider Springer Nature Link
Author Nauseef, William M.
Copyright Year 2008
Abstract The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase of phagocytes is a multi-component electron transferase that uses cytoplasmic NADPH to convert molecular oxygen to superoxide anion, consequently delivering reactive oxygen species to the site of invading microorganisms. Together with soluble factors and other phagocyte-derived agents, the resultant toxic species kill and degrade the ingested microbe. Flavocytochrome b 558, a heterodimeric protein composed of gp91 phox and p22 phox , is the membrane component of the NADPH oxidase and was previously thought to be uniquely expressed in phagocytes. Based on structural homology with gp91 phox , recent studies have defined a family of NADPH oxidase proteins (Nox) that is widely distributed throughout the plant and animal kingdoms and in many tissues in multicellular organisms. The goals of this review are to review features of the phagocyte NADPH oxidase that serve as a paradigm for exploiting oxidants for host defense, and to discuss contributions of other Nox proteins to innate immunity.
Starting Page 195
Ending Page 208
Page Count 14
File Format PDF
ISSN 18632297
Journal Springer Seminars in Immunopathology
Volume Number 30
Issue Number 3
e-ISSN 18632300
Language English
Publisher Springer-Verlag
Publisher Date 2008-05-01
Publisher Place Berlin, Heidelberg
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Nox NADPH oxidase Reactive oxygen species Flavocytochrome b 558 gp91 phox Phagocytes Internal Medicine Immunology
Content Type Text
Resource Type Article
Subject Immunology and Allergy Immunology
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