NDLI: Fumaric acid production by fermentation

Content Provider	Springer Nature Link
Author	Roa Engel, Carol A. Straathof, Adrie J. J. Zijlmans, Tiemen W. Gulik, Walter M. Wielen, Luuk A. M.
Copyright Year	2008
Abstract	The potential of fumaric acid as a raw material in the polymer industry and the increment of cost of petroleum-based fumaric acid raises interest in fermentation processes for production of this compound from renewable resources. Although the chemical process yields 112% w/w fumaric acid from maleic anhydride and the fermentation process yields only 85% w/w from glucose, the latter raw material is three times cheaper. Besides, the fermentation fixes CO2. Production of fumaric acid by Rhizopus species and the involved metabolic pathways are reviewed. Submerged fermentation systems coupled with product recovery techniques seem to have achieved economically attractive yields and productivities. Future prospects for improvement of fumaric acid production include metabolic engineering approaches to achieve low pH fermentations.
Starting Page	379
Ending Page	389
Page Count	11
File Format	PDF
ISSN	01757598
Journal	Applied Microbiology and Biotechnology
Volume Number	78
Issue Number	3
e-ISSN	14320614
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-01-24
Publisher Place	Berlin, Heidelberg
Access Restriction	Subscribed
Subject Keyword	Fumaric acid Fermentation Rhizopus species Maleate isomerase Product recovery Microbial Genetics and Genomics Microbiology Biotechnology
Content Type	Text
Resource Type	Article
Subject	Medicine Applied Microbiology and Biotechnology Biotechnology

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