NDLI: Lovastatin biosynthetic genes of Aspergillus terreus are expressed differentially in solid-state and in liquid submerged fermentation

Content Provider	Springer Nature Link
Author	Barrios González, J. Baños, J. G. Covarrubias, A. A. Garay Arroyo, A.
Copyright Year	2008
Abstract	Molecular studies were performed to establish the causes of the superior lovastatin productivity of a novel solid-state fermentation (SSF) process, in relation with liquid submerged fermentation (SmF; 20 mg/g vs. 0.65 mg/ml). In SSF, biosynthetic genes lovE and lovF transcripts accumulated to high levels from day 1 to day 7. In this period, lovE transcript showed 4.6-fold higher accumulation levels (transcription) than the highest level detected in SmF (day 5). lovF transcript showed two-fold higher expression than the highest point in SmF. In SmF, the expression was only detected clearly on day 5 and, showing a 50% decrease, on day 7. These results show that the higher lovastatin production in SSF is related to a more intense transcription of these biosynthetic genes. A strong expression of gldB gene in lovastatin SSF indicated that Aspergillus terreus senses osmotic stress during the course of SSF, but not in SmF. However, when a liquid medium of identical concentration was used in SmF, lovastatin production decreased in 50%, while lovE and lovF transcripts accumulation was 20 and six-fold lower than in SSF; showing that physiology is different in SSF, and that osmotic stress alone is not responsible for the higher gene expression in SSF.
Starting Page	179
Ending Page	186
Page Count	8
File Format	PDF
ISSN	01757598
Journal	Applied Microbiology and Biotechnology
Volume Number	79
Issue Number	2
e-ISSN	14320614
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-04-15
Publisher Place	Berlin, Heidelberg
Access Restriction	Subscribed
Subject Keyword	Solid-state fermentation Submerged fermentation Lovastatin biosynthesis gene expression Microbial Genetics and Genomics Microbiology Biotechnology
Content Type	Text
Resource Type	Article
Subject	Medicine Applied Microbiology and Biotechnology Biotechnology

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