NDLI: Continuous gluconic acid production by the yeast-like Aureobasidium pullulans in a cascading operation of two bioreactors

Content Provider	Springer Nature Link
Author	Anastassiadis, Savas Rehm, Hans Jürgen
Copyright Year	2006
Abstract	The application of a new developed process for the continuous production of gluconic acid using a cascade of two bioreactors in a continuous process is shown reaching the highest concentration of gluconic acid described in the literature for continuous culture fermentation. Very high gluconic acid concentrations of 272–308 g/l have been achieved under continuous cultivation of free-growing cells of Aureobasidium pullulans in the first bioreactor at residence times (RT) between 19.5 and 24 h with formation rates for the generic product between 12.7 and 13.9 g/(l h). Gluconic acid, 350–370 g/l, was continuously reached in the second bioreactor at a total RT of 30.8–37 h with R j of 9.2–12 g/(l h). The highest specific gluconic acid production (m p) of 3.6 g/(g h) was found in the first bioreactor at the lowest RT of 19.5 h. The highest selectivity of 93.6% was determined in the first bioreactor as well. Complete glucose consumption was obtained at 37 h total residence time in the second bioreactor. Gluconic acid, 433 g/l, was continuously produced in the second bioreactor at a total RT of 37 h.
Starting Page	541
Ending Page	548
Page Count	8
File Format	PDF
ISSN	01757598
Journal	Applied Microbiology and Biotechnology
Volume Number	73
Issue Number	3
e-ISSN	14320614
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-08-12
Publisher Place	Berlin, Heidelberg
Access Restriction	Subscribed
Subject Keyword	Gluconic acid Aureobasidium pullulans Continuous gluconic acid fermentation Continuous fermentation Continuous gluconic acid production Gluconic acid production Gluconic acid fermentation Cascade of bioreactors Microbial Genetics and Genomics Microbiology Biotechnology
Content Type	Text
Resource Type	Article
Subject	Medicine Applied Microbiology and Biotechnology Biotechnology

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