NDLI: RT1.P, rat class Ib genes related to mouse TL: evidence that CD1 molecules but not authentic TL antigens are expressed by rat thymus

Please wait, while we are loading the content...

Identification and characterization of a homologue of Bruton’s tyrosine kinase, a Tec kinase involved in B-cell development, in a modern representative of a phylogenetically ancient vertebrate

Sequence diversity present within the 5′ upstream regions of BoLA class I genes

A highly informative dinucleotide repeat polymorphism telomeric to HLA-F

A highly polymorphic microsatellite marker in the human MHC class III region, close to the BAT2 gene

Description of a new HLA-B40 allele (B * 4011) found in a Mexican individual of Nahua (Aztec) descent

Polymorphism in the Ly-17 alloantigenic system of the mouse FcgRII gene

Nucleotide sequences of the major histocompatibility complex DQA1 locus of Cercopithecus monkeys

Major histocompatibility complex DQA1 nucleotide sequences of gelada baboon (Theropithecus gelada), olive baboon (Papio anubis), and yellow baboon (Papio cynocephalus)

Immunogenetics : Volume 46, Issue 3, July 1997

Immunogenetics : Volume 46, Issue 2, June 1997

Immunogenetics : Volume 46, Issue 1, May 1997

Immunogenetics : Volume 45

RT1.P, rat class Ib genes related to mouse TL: evidence that CD1 molecules but not authentic TL antigens are expressed by rat thymus

Content Provider	Springer Nature Link
Author	Matsuura, A. Takayama, Shinichi Kinebuchi, Miyuki Hashimoto, Yuji Kasai, Kiyoshi Kozutsumi, Daisuke Ichimiya, Shingo Honda, Ryoichi Natori, Takashi Kikuchi, Kokichi
Copyright Year	1997
Abstract	CD1 and TL were once thought to be genetic homologues because of their thymus-specific expression. We investigated their equivalents in the rat to clarify whether their structure and pattern of expression are conserved in rodents. Two rat class Ib genes, containing 3′ sequences very similar to mouse TL, were identified and designated RT1.P. Neither of them, however, can encode ordinary class I molecules due to the accumulation of harmful mutations in the 5′ regions that are unique to RT1.P, while the 3′TL-like regions still retain protein-coding capacity. Comparison of the structural organization of three types of TL family genes, which include mouse T3/T18-encoding TL antigens, mouse T1/T16, and rat RT1.P1/P2 pseudogenes, revealed the presence of a clear demarcation between the type-specific and TL-specific sequences at intron 3. This finding suggests that recombination plays an important role in creating the TL family genes in rodents. Characteristic features of TL, such as a low level of polymorphism and linkage to the major histocompatibility complex, were also observed in the rat. On the other hand, rat CD1 molecules were expressed at a high level on the surface of thymocytes. Absence of authentic TL antigens and thymic expression of CD1d molecules in the rat suggest the plasticity and conservation of class Ib genes in rodent evolution. Functions of TL may be substituted with CD1 or other class Ib molecules expressed by rat thymus.
Starting Page	293
Ending Page	306
Page Count	14
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	46
Issue Number	4
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	1997-07-22
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Active MHC class Ib genes in rat are pseudogenes in the mouse

RT1.L: a family of MHC class Ib genes of the rat major histocompatibility complex with a distinct promoter structure

HLA class I molecules are associated with CD1a heavy chains on normal human thymus cells.

Murine MHC class Ib gene, H2-M2, encodes a conserved surface-expressed glycoprotein

Promoter structures suggest independent translocations of ancestral rat RT1.A and mouse H2-K class I genes

Open reading frame sequencing and structure-based alignment of polypeptides encoded by RT1-Bb, RT1-Ba, RT1-Db, and RT1-Da alleles

Thymus-leukemia (TL) antigens of the mouse. Analysis of TL mRNA and TL cDNA TL+ and TL- strains.

Detection of transcripts for a soluble form of the RT1-E MHC class Ib molecule in rat placenta

Structural organization, sequence analysis, and physical mapping of the Grc-linked class Ib gene RT1.S3 in the rat

RT1.P, rat class Ib genes related to mouse TL: evidence that CD1 molecules but not authentic TL antigens are expressed by rat thymus

Similar Documents

Active MHC class Ib genes in rat are pseudogenes in the mouse

RT1.L: a family of MHC class Ib genes of the rat major histocompatibility complex with a distinct promoter structure

HLA class I molecules are associated with CD1a heavy chains on normal human thymus cells.

Murine MHC class Ib gene, H2-M2, encodes a conserved surface-expressed glycoprotein

Promoter structures suggest independent translocations of ancestral rat RT1.A and mouse H2-K class I genes

Open reading frame sequencing and structure-based alignment of polypeptides encoded by RT1-Bb, RT1-Ba, RT1-Db, and RT1-Da alleles

Thymus-leukemia (TL) antigens of the mouse. Analysis of TL mRNA and TL cDNA TL+ and TL- strains.

Detection of transcripts for a soluble form of the RT1-E MHC class Ib molecule in rat placenta

Structural organization, sequence analysis, and physical mapping of the Grc-linked class Ib gene RT1.S3 in the rat

RT1.P, rat class Ib genes related to mouse TL: evidence that CD1 molecules but not authentic TL antigens are expressed by rat thymus