NDLI: A new DR7-DQ8 haplotype resulting from a recombination between the DQA1 and DQB1 loci in a leukemic patient of Caucasoid origin

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A new DR7-DQ8 haplotype resulting from a recombination between the DQA1 and DQB1 loci in a leukemic patient of Caucasoid origin

Content Provider	Springer Nature Link
Author	Tiercy, Jean Marie Villard, Jean
Copyright Year	2004
Abstract	Meiotic recombinations within the HLA-DR/DQ subregion are seldomly observed. However the high number of unusual DRB1-DQB1 allelic combinations underline the importance of crossover in shaping the class II haplotypic diversity. We present here the first report of a DQA1-DQB1 recombination event in a leukemic patient as detected by complete class II molecular typing of the family, including analysis of the DQCAR microsatellite. The recombination that occurred on the maternal chromosomes led to the unusual DR7-DQ8 haplotype characterized by the DRB10701-DRB401030102N-DQA10201-DQB10302 alleles. Because the patient had no HLA-identical sibling donor, a search for an unrelated hematopoietic stem cell donor was initiated. Out of three potential donors, only one HLA-A/-B/-C/DRB1-compatible but DQB1-mismatched donor could be identified.
Starting Page	301
Ending Page	303
Page Count	3
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	56
Issue Number	4
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2004-06-23
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Recombination DQA1-DQB1 haplotype DQCAR Unrelated HSCT
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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