NDLI: Immunoglobulin D (IgD) of Atlantic cod has a unique structure

Content Provider	Springer Nature Link
Author	Stenvik, Jørgen Jørgensen, Trond Ø.
Copyright Year	2000
Abstract	A new immunoglobulin heavy-chain gene with some homology to mammalian IgD was recently cloned from the channel catfish and Atlantic salmon, two species of teleost fish. We have cloned and sequenced a new H-chain gene from Atlantic cod (Gadus morhua L.) which has clear similarities to these genes, but which also differs in several ways. The similarities of catfish, salmon, and cod delta to the mammalian delta genes are sequence homology, location immediately downstream of IgM (mu), and expression by alternative splicing rather than class switching. A unique feature of catfish, salmon, and cod delta is the chimeric nature of the gene product, as the μ1 exon is spliced to the δ1 exon. Several unique features of cod IgD were found: (1) a deletion of the δ3, δ4, δ5, and δ6 domains described in catfish and salmon IgD, (2) a tandem duplication of a part of the delta locus including the δ1 and δ2 domains, (3) the presence of a truncated δ7 domain downstream of the δTM exons, and (4) the separation of the duplicated domains by a short exon (δy) which has homology to a conserved part of the transmembrane exon 1 (TM1) of some H-chain isotypes. This unique organization of the delta locus of cod probably developed after the evolutionary split from the catfish and salmon branches.
Starting Page	452
Ending Page	461
Page Count	10
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	51
Issue Number	6
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2000-05-04
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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