NDLI: Footprints of intragenic recombination at HLA loci

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Evolutionary history and mechanism of the Drosophila Cecropin gene family

Footprints of intragenic recombination at HLA loci

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Footprints of intragenic recombination at HLA loci

Content Provider	Springer Nature Link
Author	Takahata, N. Satta, Yoko
Copyright Year	1998
Abstract	To evaluate the effect of balancing selection and intragenic recombination (or gene conversion) at six individual HLA loci, synonymous nucleotide diversity in different exon groups is examined within (πw) and between (πb) allelic lineages that may be defined by either serological or DNA sequence differences. Both π values are high in exons which encode for the peptide binding region (PBR) and tend to decrease in other exons. The value of πw is significantly smaller than that of πb in any exon of any locus. However, even πw is much greater than nucleotide diversity at non-HLA loci. These observations provide additional strong evidence for the operation of balancing selection in PBR-encoding exons and its indirect effects on polymorphism at linked neighboring regions. It appears that allelic lineages have generally evolved in isolation but the linkage relationships within and between exons are incomplete throughout the long evolutionary history. To quantify intragenic recombination and account for the large discrepancy between the HLA and non-HLA diversity, a population genetics model is analyzed with special reference to the evolution of modern humans. The analysis suggests that the recombination rate between two sites 1000 base pairs apart is about 10–5 per generation and that the effective size of human populations (equivalent roughly to the number of breeding individuals in a randomly mating population) has dropped from 105 to 104 in most of the Quaternary. One possibility for this reduction is discussed.
Starting Page	430
Ending Page	441
Page Count	12
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	47
Issue Number	6
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	1998-04-23
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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A peculiar case of recombination at HLA-A locus.

Contrasting Roles of Interallelic Recombination at the Hla-a and Hla-B Loci

Novel alleles at the HLA-DRB1 and -DQB1 loci.

Selection, convergence, and intragenic recombination in HLA diversity

Characterization of 236 novel alleles at the HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1 loci from China Marrow Donor Program.

Characterization of 104 novel alleles at the HLA-A, -B, and -DRB1 loci from National Marrow Donor Program volunteer donors.

The Transposable Element Ds Affects the Pattern of Intragenic Recombination at the bz and R Loci in Maize

The Transposable Elements Ds Affects the Pattern of Intragenic - Recombination at the Bz and R Loci in Maize

A new allele, HLA-G010120, is generated by a recombination event between HLA-G01010101/02 and HLA-G*01010201.

Footprints of intragenic recombination at HLA loci

Similar Documents

A peculiar case of recombination at HLA-A locus.

Contrasting Roles of Interallelic Recombination at the Hla-a and Hla-B Loci

Novel alleles at the HLA-DRB1 and -DQB1 loci.

Selection, convergence, and intragenic recombination in HLA diversity

Characterization of 236 novel alleles at the HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1 loci from China Marrow Donor Program.

Characterization of 104 novel alleles at the HLA-A, -B, and -DRB1 loci from National Marrow Donor Program volunteer donors.

The Transposable Element Ds Affects the Pattern of Intragenic Recombination at the bz and R Loci in Maize

The Transposable Elements Ds Affects the Pattern of Intragenic - Recombination at the Bz and R Loci in Maize

A new allele, HLA-G*010120, is generated by a recombination event between HLA-G*01010101/02 and HLA-G*01010201.

Footprints of intragenic recombination at HLA loci

A new allele, HLA-G010120, is generated by a recombination event between HLA-G01010101/02 and HLA-G*01010201.