NDLI: Characterization of immunoglobulin gamma 1 from a monotreme, Tachyglossus aculeatus

Content Provider	Springer Nature Link
Author	Belov, Katherine Hellman, Lars Cooper, Desmond W.
Copyright Year	2002
Abstract	A full-length immunoglobulin gamma clone from the echidna (Tachyglossus aculeatus) was isolated from a spleen cDNA library. The clone was 1,664 base pairs long and encoded the entire open reading frame, incorporating the V, D, J and C regions. The echidna clone had approximately 41% identity and 67% similarity at the amino acid level with both marsupial and eutherian IgG molecules. The presence of IgG in the monotremes confirms that the appearance of IgG occurred prior to the separation of the three extant mammalian lineages, but after their separation from the reptilian lineage, pinpointing the date to between 310 and 170 million years ago. Phylogenetic analyses using the immunoglobulin sequence data strongly support the 'Theria' hypothesis, with the monotreme lineage diverging prior to the separation of the marsupial and eutherian lineages.
Starting Page	1065
Ending Page	1071
Page Count	7
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	53
Issue Number	12
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2002-02-08
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Immunology Human Genetics Gene Function Cell Biology Allergology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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Characterization of immunoglobulin gamma 1 from a monotreme, Tachyglossus aculeatus