NDLI: Molecular characterization of major histocompatibility complex class I genes from the giant panda (Ailuropoda melanoleuca)

Content Provider	Springer Nature Link
Author	Pan, Hui Juan Wan, Qiu Hong Fang, Sheng Guo
Copyright Year	2008
Abstract	The major histocompatibility complex class I genes play crucial roles in the adaptive immune system of vertebrates against intracellular pathogens. To date, no class I genes from the giant panda (Ailuropoda melanoleuca) has been reported, even none from species of Ursidae. In this study, we successfully identified three class I genes from a giant panda bacterial artificial chromosome library and designated them as Aime-128, 152, and 1906, respectively. Pairwise sequence alignments revealed that (1) the Aime-1906 always possessed the lowest identities (52–86%) in different regions compared with the Aime-128 and 152 and (2) the Aime-128 also varied from the Aime-152 in the regions of 5′ untranslated region (UTR), 3′ UTR, and exon1, whose similarities were 83%, 87%, and 91%, respectively. Comparison of structure characteristics indicated that the Aime-128 possessed all conserved amino acids important to the function of antigen presentation while the Aime-152 and 1906 presented two and five mutated residues. Analysis of phylogenetic trees demonstrated that the Aime-128, 152, and 1906 were clustered into three different branches with 99% or 100% bootstrap values. As a result, these three kinds of evidence supported that the Aime-1906, 152, and 128 should be derived from different loci. Furthermore, in view of a prestop codon in the exon 7 and patterns of amino acid replacement within alleles, the Aime-1906 gene is predicted to be a nonclassical locus, which is most closely related to dog leukocyte antigen 79 in the phylogenetic tree constructed with various mammalian class I loci.
Starting Page	185
Ending Page	193
Page Count	9
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	60
Issue Number	3-4
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-02-22
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	MHC isolation Locus comparison Phylogenetic tree Cell Biology Allergology Immunology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Isolation and characterization of class I MHC genes in the giant panda (Ailuropoda melanoleuca)

Low major histocompatibility complex class II DQA diversity in the Giant Panda (Ailuropoda melanoleuca)

Haplotype characterization of transcribed ovine major histocompatibility complex (MHC) class I genes

Low major histocompatibility complex class II DQA diversity in the Giant Panda (Ailuropoda melanoleuca)

Mhc class I genes of the cichlid fish Oreochromis niloticus

Characterization of major histocompatibility complex class I and class II genes from the Tasmanian devil (Sarcophilus harrisii)

Data from: Patterns of genetic differentiation at MHC class I genes and microsatellites identify conservation units in the giant panda (Dataset)

Characterization and locus-specific typing of MHC class I genes in the red-billed gull (Larus scopulinus) provides evidence for major, minor, and nonclassical loci

A third broad lineage of major histocompatibility complex (MHC) class I in teleost fish; MHC class II linkage and processed genes

Molecular characterization of major histocompatibility complex class I genes from the giant panda (Ailuropoda melanoleuca)

Similar Documents

Isolation and characterization of class I MHC genes in the giant panda (Ailuropoda melanoleuca)

Low major histocompatibility complex class II DQA diversity in the Giant Panda (Ailuropoda melanoleuca)

Haplotype characterization of transcribed ovine major histocompatibility complex (MHC) class I genes

Low major histocompatibility complex class II DQA diversity in the Giant Panda (Ailuropoda melanoleuca)

Mhc class I genes of the cichlid fish Oreochromis niloticus

Characterization of major histocompatibility complex class I and class II genes from the Tasmanian devil (Sarcophilus harrisii)

Data from: Patterns of genetic differentiation at MHC class I genes and microsatellites identify conservation units in the giant panda (Dataset)

Characterization and locus-specific typing of MHC class I genes in the red-billed gull (Larus scopulinus) provides evidence for major, minor, and nonclassical loci

A third broad lineage of major histocompatibility complex (MHC) class I in teleost fish; MHC class II linkage and processed genes

Molecular characterization of major histocompatibility complex class I genes from the giant panda (Ailuropoda melanoleuca)