NDLI: Modulation of channel activity and gadolinium block of MscL by static magnetic fields

Content Provider	Springer Nature Link
Author	Petrov, Evgeny Martinac, Boris
Copyright Year	2006
Abstract	The magnetic field of the Earth has for long been known to influence the behaviour and orientation of a variety of living organisms. Experimental studies of the magnetic sense have, however, been impaired by the lack of a plausible cellular and/or molecular mechanism providing meaningful explanation for detection of magnetic fields by these organisms. Recently, mechanosensitive (MS) ion channels have been implied to play a role in magnetoreception. In this study we have investigated the effect of static magnetic fields (SMFs) of moderate intensity on the activity and gadolinium block of MscL, the bacterial MS channel of large conductance, which has served as a model channel to study the basic physical principles of mechanosensory transduction in living cells. In addition to showing that direct application of the magnetic field decreased the activity of the MscL channel, our study demonstrates for the first time that SMFs can reverse the effect of gadolinium, a well-known blocker of MS channels. The results of our study are consistent with a notion that (1) the effects of SMFs on the MscL channels may result from changes in physical properties of the lipid bilayer due to diamagnetic anisotropy of phospholipid molecules and consequently (2) cooperative superdiamagnetism of phospholipid molecules under influence of SMFs could cause displacement of Gd3+ ions from the membrane bilayer and thus remove the MscL channel block.
Starting Page	95
Ending Page	105
Page Count	11
File Format	PDF
ISSN	01757571
Journal	European Biophysics Journal
Volume Number	36
Issue Number	2
e-ISSN	14321017
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-11-07
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	MscL SMFs Gadolinium Patch-clamp Bacteria Neurobiology Animal Physiology Plant Physiology Biochemistry Cell Biology Biophysics/Biomedical Physics
Content Type	Text
Resource Type	Article
Subject	Medicine Biophysics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Functional similarities between heterogeneously and homogenously expressed MscL constructs

Ca2+ current of frog vestibular hair cells is modulated by intracellular ATP but not by long-lasting depolarisation

Magnetic nanoparticles for “smart liposomes”

A novel technique to study pore-forming peptides in a natural membrane

Effects of gadolinium and static magnetic fields on MscL channel activity

Patch clamp characterization of the effect of cardiolipin on MscS of E. coli

Travel Fellowships

Satellite Meetings

Scientific Program

Modulation of channel activity and gadolinium block of MscL by static magnetic fields

Similar Documents

Functional similarities between heterogeneously and homogenously expressed MscL constructs

Ca2+ current of frog vestibular hair cells is modulated by intracellular ATP but not by long-lasting depolarisation

Magnetic nanoparticles for “smart liposomes”

A novel technique to study pore-forming peptides in a natural membrane

Effects of gadolinium and static magnetic fields on MscL channel activity

Patch clamp characterization of the effect of cardiolipin on MscS of E. coli

Travel Fellowships

Satellite Meetings

Scientific Program

Modulation of channel activity and gadolinium block of MscL by static magnetic fields