NDLI: Interactions of hybrid gold–tannic acid nanoparticles with human serum albumin

Content Provider	Springer Nature Link
Author	Sekowski, Szymon Tomaszewska, Emilia Soliwoda, Katarzyna Celichowski, Grzegorz Grobelny, Jaroslaw
Copyright Year	2016
Abstract	Nanoparticles present a wide spectrum of chemical, biological, and physical properties which result in their usage in many branches of science. We present an investigation of the interaction between human serum albumin and hybrid gold–tannic acid nanoparticles synthesized via a chemical reduction method. The results obtained demonstrate that tannic acid can be a very effective reducing and stabilizing agent and allows monodisperse hybrid gold nanomaterial to be obtained. The synthesized hybrid gold–tannic acid nanoparticles strongly interact with human serum albumin by formation of protein–corona complexes. The strength of the interaction with albumin depends on the number of tannic acid molecules on the surface of the nanoparticles and the presence of citric acid. Nanoparticles of large size and rich in tannic acid react more strongly with the protein [K SV = (8.00 ± 0.2) × 105 M−1] compared with smaller ones [K SV = (6.83 ± 0.5) × 104 M−1] containing citric acid and low concentration of tannic acid.
Starting Page	49
Ending Page	57
Page Count	9
File Format	PDF
ISSN	01757571
Journal	European Biophysics Journal
Volume Number	46
Issue Number	1
e-ISSN	14321017
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-05-10
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hybrid nanoparticles Gold nanoparticles Human serum albumin Tannic acid Fluorescence spectroscopy Biochemistry Biological and Medical Physics, Biophysics Cell Biology Neurobiology Membrane Biology Nanotechnology
Content Type	Text
Resource Type	Article
Subject	Medicine Biophysics

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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