NDLI: Cooperative lattice dynamics and anomalous fluctuations of microtubules

Content Provider	Springer Nature Link
Author	Mohrbach, Hervé Johner, Albert Kulić, Igor M.
Copyright Year	2011
Abstract	Microtubules have been in the focus of biophysical research for several decades. However, the confusing and mutually contradictory results regarding their elasticity and fluctuations have cast doubt on their present understanding. In this paper, we present the empirical evidence for the existence of discrete guanosine diphosphate (GDP)–tubulin fluctuations between a curved and a straight configuration at room temperature as well as for conformational tubulin cooperativity. Guided by a number of experimental findings, we build the case for a novel microtubule model, with the principal result that microtubules can spontaneously form micron-sized cooperative helical states with unique elastic and dynamic features. The polymorphic dynamics of the microtubule lattice resulting from the tubulin bistability quantitatively explains several experimental puzzles, including anomalous scaling of dynamic fluctuations of grafted microtubules, their apparent length–stiffness relation, and their remarkable curved–helical appearance in general. We point out that the multistability and cooperative switching of tubulin dimers could participate in important cellular processes, and could in particular lead to efficient mechanochemical signaling along single microtubules.
Starting Page	217
Ending Page	239
Page Count	23
File Format	PDF
ISSN	01757571
Journal	European Biophysics Journal
Volume Number	41
Issue Number	2
e-ISSN	14321017
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-12-16
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Microtubules Allostery Signaling Cell mechanics Cytoskeleton Biopolymers Membrane Biology Biophysics and Biological Physics Nanotechnology Biochemistry Neurobiology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Medicine Biophysics

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