NDLI: Finding the Needles in the Metagenome Haystack

Content Provider	Springer Nature Link
Author	Kowalchuk, George A. Speksnijder, Arjen G. C. L. Zhang, Kun Goodman, Robert M. Veen, Johannes A.
Copyright Year	2007
Abstract	In the collective genomes (the metagenome) of the microorganisms inhabiting the Earth’s diverse environments is written the history of life on this planet. New molecular tools developed and used for the past 15 years by microbial ecologists are facilitating the extraction, cloning, screening, and sequencing of these genomes. This approach allows microbial ecologists to access and study the full range of microbial diversity, regardless of our ability to culture organisms, and provides an unprecedented access to the breadth of natural products that these genomes encode. However, there is no way that the mere collection of sequences, no matter how expansive, can provide full coverage of the complex world of microbial metagenomes within the foreseeable future. Furthermore, although it is possible to fish out highly informative and useful genes from the sea of gene diversity in the environment, this can be a highly tedious and inefficient procedure. Microbial ecologists must be clever in their pursuit of ecologically relevant, valuable, and niche-defining genomic information within the vast haystack of microbial diversity. In this report, we seek to describe advances and prospects that will help microbial ecologists glean more knowledge from investigations into metagenomes. These include technological advances in sequencing and cloning methodologies, as well as improvements in annotation and comparative sequence analysis. More significant, however, will be ways to focus in on various subsets of the metagenome that may be of particular relevance, either by limiting the target community under study or improving the focus or speed of screening procedures. Lastly, given the cost and infrastructure necessary for large metagenome projects, and the almost inexhaustible amount of data they can produce, trends toward broader use of metagenome data across the research community coupled with the needed investment in bioinformatics infrastructure devoted to metagenomics will no doubt further increase the value of metagenomic studies in various environments.
Starting Page	475
Ending Page	485
Page Count	11
File Format	PDF
ISSN	00953628
Journal	Microbial Ecology
Volume Number	53
Issue Number	3
e-ISSN	1432184X
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-03-08
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Nature Conservation Geoecology/Natural Processes Ecology Microbiology
Content Type	Text
Resource Type	Article
Subject	Soil Science Ecology Ecology, Evolution, Behavior and Systematics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Finding the Needles in the Metagenome Haystack

Finding the Needles in the Metagenome Haystack

Microbial Environmental Genomics

Heterotrophic Fixation of CO2 in Soil

Rickettsia Infection in Natural Leech Populations

Introducing the ‘New’ Microbial Ecology

Diversity of Phytases in the Rumen

Phage Diversity in a Methanogenic Digester

Aspects of marker/reporter stability and selectivity in soil microbiology

Finding the Needles in the Metagenome Haystack

Similar Documents

Finding the Needles in the Metagenome Haystack

Finding the Needles in the Metagenome Haystack

Microbial Environmental Genomics

Heterotrophic Fixation of CO2 in Soil

Rickettsia Infection in Natural Leech Populations

Introducing the ‘New’ Microbial Ecology

Diversity of Phytases in the Rumen

Phage Diversity in a Methanogenic Digester

Aspects of marker/reporter stability and selectivity in soil microbiology

Finding the Needles in the Metagenome Haystack