NDLI: The Effects of Tributyltin (TBT) and 3,3′,4,4′,5-Pentachlorobiphenyl (PCB-126) Mixtures on Antibody Responses and Phagocyte Oxidative Burst Activity in Channel Catfish, Ictalurus punctatus

Content Provider	Springer Nature Link
Author	Regala, R. P. Rice, C. D. Schwedler, T. E. Dorociak, I. R.
Copyright Year	2001
Abstract	The organotin tributyltin (TBT) is an antifouling biocide used in marine paints and is a common pollutant in harbor estuaries. We previously demonstrated that the immune system of channel catfish, Ictalurus punctatus, is a sensitive target organ of TBT. Exposure strongly suppresses humoral immune responses. Harbor estuaries often contain polychlorinated biphenyls (PCBs) due to their ubuquitous distribution. The coplanar congener 3,3′,4,4′5′-polychlorinated biphenyl (PCB-126) is also immunotoxic to channel catfish, but it suppresses only the innate immune responses and only at high doses. In this study we exposed channel catfish to TBT, PCB-126, or both in mixtures, with canola oil (CO) serving as the carrier control. Antibody responses to Vibrio anguillarum and phagocyte oxidative burst activity were measured after (1) a single dose of 0.01 or 1 mg/kg of each or both in combination, and (2) six injections of 1.7 or 170 μg/kg of each (or in combination) given every 3 days over a 16-day period to yield a cumulative dose of 0.01 or 1 mg/kg, respectively. We measured antibody responses to V. anguillarum 21 days after immunization and oxidative burst activities 14 and 21 days after the final treatment. The highest dose of TBT suppressed antibody responses after a single exposure. The high dose of PCB-126 also suppressed antibody responses. The addition of PCB-126 to TBT doses did not alter the antibody responses beyond the effects of TBT alone. In the repeated exposure group, only the high dose of TBT suppressed antibody responses. In animals exposed to mixtures, high levels of PCB-126 enhanced suppression associated with low levels of TBT, whereas PCB-126 protected against suppression associated with high levels of TBT. Single exposures to TBT or PCB-126 suppressed phagocyte oxidative burst activity. In animals exposed to mixtures, as a single exposure, the addition of a low dose PCB-126 protected against low dose TBT-related oxidative burst activity suppression. In the repeated exposure groups TBT suppressed oxidative burst activity, but only at the highest dose on day 21, while high doses of PCB-126 suppressed activity on day 14. Furthermore, low levels of PCB-126 reversed the suppressed oxidative burst activity associated with high levels of TBT on day 21. Overall, this study demonstrates moderate additivity in terms of the immunotoxicity of TBT and PCB-126 mixtures using these two endpoints of immune function in the channel catfish model.
Starting Page	386
Ending Page	391
Page Count	6
File Format	PDF
ISSN	00904341
Journal	Archives of Environmental Contamination and Toxicology
Volume Number	40
Issue Number	3
e-ISSN	14320703
Language	English
Publisher	Springer-Verlag
Publisher Date	2001-03-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Pollution Health, Toxicology and Mutagenesis Medicine Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Assessment of the roles of antioxidant enzymes and glutathione in 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126)-induced oxidative stress in the brain tissues of rats after subchronic exposure

The Effects of 3,3′,4,4′,5-Pentachlorobiphenyl (PCB 126) on Mink (Mustela vison) Reproduction and Kit Survivability and Growth

Developmental Toxicity of PCB 126 (3,3′,4,4′,5-Pentachlorobiphenyl) in Nestling American Kestrels (Falco sparverius)

Dietary accumulation and biochemical responses of juvenile rainbow trout (Oncorhynchus mykiss) to 3,3',4,4',5-pentachlorobiphenyl (PCB 126).

Assessment of the roles of antioxidant enzymes and glutathione in 3,3′,4,4′,5-Pentachlorobiphenyl (PCB 126)-induced oxidative stress in the brain tissues of rats after subchronic exposure

Effects of Vertically Transferred 3,3',4,4',5-Pentachlorobiphenyl (PCB-126) on the Reproductive Development of Female Rats

3,3′,4,4′,5-Pentachlorobiphenyl (PCB 126) Decreases Hepatic and Systemic Ratios of Epoxide to Diol Metabolites of Unsaturated Fatty Acids in Male Rats

Effects of Vertically Transferred 3,3',4,4',5-Pentachlorobiphenyl on Gene Expression in the Ovaries of Immature Sprague-Dawley Rats

Identification of lipidomic markers of chronic 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126) exposure in the male rat liver

The Effects of Tributyltin (TBT) and 3,3′,4,4′,5-Pentachlorobiphenyl (PCB-126) Mixtures on Antibody Responses and Phagocyte Oxidative Burst Activity in Channel Catfish, Ictalurus punctatus

Similar Documents

Assessment of the roles of antioxidant enzymes and glutathione in 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126)-induced oxidative stress in the brain tissues of rats after subchronic exposure

The Effects of 3,3′,4,4′,5-Pentachlorobiphenyl (PCB 126) on Mink (Mustela vison) Reproduction and Kit Survivability and Growth

Developmental Toxicity of PCB 126 (3,3′,4,4′,5-Pentachlorobiphenyl) in Nestling American Kestrels (Falco sparverius)

Dietary accumulation and biochemical responses of juvenile rainbow trout (Oncorhynchus mykiss) to 3,3',4,4',5-pentachlorobiphenyl (PCB 126).

Assessment of the roles of antioxidant enzymes and glutathione in 3,3′,4,4′,5-Pentachlorobiphenyl (PCB 126)-induced oxidative stress in the brain tissues of rats after subchronic exposure

Effects of Vertically Transferred 3,3',4,4',5-Pentachlorobiphenyl (PCB-126) on the Reproductive Development of Female Rats

3,3′,4,4′,5-Pentachlorobiphenyl (PCB 126) Decreases Hepatic and Systemic Ratios of Epoxide to Diol Metabolites of Unsaturated Fatty Acids in Male Rats

Effects of Vertically Transferred 3,3',4,4',5-Pentachlorobiphenyl on Gene Expression in the Ovaries of Immature Sprague-Dawley Rats

Identification of lipidomic markers of chronic 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126) exposure in the male rat liver

The Effects of Tributyltin (TBT) and 3,3′,4,4′,5-Pentachlorobiphenyl (PCB-126) Mixtures on Antibody Responses and Phagocyte Oxidative Burst Activity in Channel Catfish, Ictalurus punctatus