NDLI: Effectiveness of Various Exposure Metrics in Defining Dose-Response Relationships for Mink (Mustela vison) Exposed to Polychlorinated Biphenyls

Content Provider	Springer Nature Link
Author	Fuchsman, P. C. Barber, T. R. Bock, M. J.
Copyright Year	2007
Abstract	We conducted a quantitative analysis of published results from more than 50 tests of polychlorinated biphenyl (PCB) effects on mink reproduction, which provided a basis for evaluating how well different methods of measuring and assessing PCB concentrations can approximate a toxicologically relevant dose for this endpoint. Several dose metrics were identified for comparison. Dietary dose metrics included the daily intake of total PCBs and the daily intake of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity equivalence concentrations (TECs), calculated using World Health Organization toxicity equivalence factors (TEFs). Internal dose metrics included whole-body total PCBs, whole-body TECs calculated using World Health Organization TEFs, and whole-body TECs calculated using alternative TEFs specifically identified for internal dose assessment. Accounting for the bioaccumulative potential (i.e., internal dose) of ingested PCBs proved to be more important than accounting for the concentrations of dioxin-like PCB congeners in explaining the observed variation in reproductive success. This was true regardless of whether internal doses were estimated from dietary data based on homolog concentrations (whole-body total PCBs) or congener concentrations (whole-body TECs). For each of the PCB dose metrics, a range of toxicity reference values is identified based on the species-specific PCB toxicity database compiled for this evaluation.
Starting Page	130
Ending Page	144
Page Count	15
File Format	PDF
ISSN	00904341
Journal	Archives of Environmental Contamination and Toxicology
Volume Number	54
Issue Number	1
e-ISSN	14320703
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-10-18
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Soil Science & Conservation Environment Forestry Ecology Agriculture Terrestrial Pollution
Content Type	Text
Resource Type	Article
Subject	Pollution Health, Toxicology and Mutagenesis Medicine Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Chronic Oral Exposure to Bunker C Fuel Oil Causes Adrenal Insufficiency in Ranch Mink (Mustela vison)

The Effects of 3,3′,4,4′,5-Pentachlorobiphenyl (PCB 126) on Mink (Mustela vison) Reproduction and Kit Survivability and Growth

Polychlorinated Dibenzo-p-Dioxins, Polychlorinated Dibenzofurans, and Coplanar Polychlorinated Biphenyls in Human Milk in Osaka City, Japan

Organochlorine Pesticides, Polychlorinated Biphenyls, and Polybrominated Diphenyl Ethers in Irrawaddy Dolphins from India

Time- and Tissue-Dependent Polychlorinated Biphenyl Residues in Hairless Mice After Exposure to Polychlorinated Biphenyl-Contaminated Soil

Nondestructive Scat Sampling in Assessment of Mink (Mustela vison) Exposed to Polychlorinated Dibenzofurans (PCDFs)

Polychlorinated Dibenzo-p-Dioxins, Dibenzofurans, and Dioxin-Like Polychlorinated Biphenyls in Sediment and Mussel Samples from Kentucky Lake, USA

Occurrence of Polychlorinated Biphenyls and Polybrominated Diphenyl Ethers in Belgian Human Adipose Tissue Samples

Spatial Distribution of Polychlorinated Biphenyls in Coastal Marine Sediments Receiving Industrial Effluents in Kuwait

Effectiveness of Various Exposure Metrics in Defining Dose-Response Relationships for Mink (Mustela vison) Exposed to Polychlorinated Biphenyls

Similar Documents

Chronic Oral Exposure to Bunker C Fuel Oil Causes Adrenal Insufficiency in Ranch Mink (Mustela vison)

The Effects of 3,3′,4,4′,5-Pentachlorobiphenyl (PCB 126) on Mink (Mustela vison) Reproduction and Kit Survivability and Growth

Polychlorinated Dibenzo-p-Dioxins, Polychlorinated Dibenzofurans, and Coplanar Polychlorinated Biphenyls in Human Milk in Osaka City, Japan

Organochlorine Pesticides, Polychlorinated Biphenyls, and Polybrominated Diphenyl Ethers in Irrawaddy Dolphins from India

Time- and Tissue-Dependent Polychlorinated Biphenyl Residues in Hairless Mice After Exposure to Polychlorinated Biphenyl-Contaminated Soil

Nondestructive Scat Sampling in Assessment of Mink (Mustela vison) Exposed to Polychlorinated Dibenzofurans (PCDFs)

Polychlorinated Dibenzo-p-Dioxins, Dibenzofurans, and Dioxin-Like Polychlorinated Biphenyls in Sediment and Mussel Samples from Kentucky Lake, USA

Occurrence of Polychlorinated Biphenyls and Polybrominated Diphenyl Ethers in Belgian Human Adipose Tissue Samples

Spatial Distribution of Polychlorinated Biphenyls in Coastal Marine Sediments Receiving Industrial Effluents in Kuwait

Effectiveness of Various Exposure Metrics in Defining Dose-Response Relationships for Mink (Mustela vison) Exposed to Polychlorinated Biphenyls