NDLI: Enhanced Inhibitory Effects of TBT Chloride on the Development of F1 Rats

Content Provider	Springer Nature Link
Author	Asakawa, H. Tsuda, M. Kaido, T. Hosokawa, M. Sugaya, C. Iue, Y. Kudo, Y. Satoh, T. Katagiri, H. Akita, H. Saji, M. Wakasa, M. Negishi, T. Tashiro, T. Aizawa, Y.
Copyright Year	2009
Abstract	Neurotoxicity is one of the major effects of tributyltin (TBT). The effects on the next generation of F1 rats exposed to TBT via the placenta and their dams’ milk may be stronger than those on adults. Pregnant Wister rats were exposed to TBT at 0 and 125 ppm in their food. Half of the female F1 rats in both groups were exposed to TBT at 125 ppm in their food from 9 to 15 weeks of age. Female F1 rats were divided into the following groups: the control-control (CC) group, with no exposure; the TBT-control (TC) group, exposed to TBT via the placenta and their dams’ milk; the control-TBT (CT) group, exposed to TBT via their food from 9 to 15 weeks of age; and the TBT-TBT (TT) group, exposed to TBT via the placenta, their dams’ milk, and their food (n = 10/group). After administration, an open-field test and prepulse inhibition (PPI) test were performed at 15 weeks of age. The mean body weights of the TC and TT groups were significantly lower than that of the CC group from 9 to 15 weeks of age. The mean relative thymus weight of the TC and TT groups was significantly lower than that of the CC group. In the open-field test, a marked decrease in the total locomotion distance was observed in the TT group. The mean values in the TT and TC groups were significantly lower than that in the CC group. For the locomotion distance between 15 and 20 min, the mean values in the CT, TC, and TT groups were significantly lower than that in the CC group. The mean locomotor distance between 25 and 30 min in the TT group was significantly lower than that in the CC and TC groups. The mean values of instances of wall rearing in the TC, CT, and TT groups were significantly lower than that in the CC group. The mean value of face washing or body washing in the TT group was significantly lower than that in the CT group. There were no significant differences in indexes of the PPI test. Exposure to TBT via the placenta and their dams’ milk inhibited the development of F1 rats, which continued after weaning. Inhibition of the rats’ activity induced by exposure to TBT via the placenta and their dams’ milk and/or via their food was suggested. The effects were most evident in the TT group.
Starting Page	1065
Ending Page	1073
Page Count	9
File Format	PDF
ISSN	00904341
Journal	Archives of Environmental Contamination and Toxicology
Volume Number	58
Issue Number	4
e-ISSN	14320703
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-11-25
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Environmental Monitoring/Analysis Soil Science & Conservation Environmental Chemistry Environmental Health Pollution Ecotoxicology
Content Type	Text
Resource Type	Article
Subject	Pollution Health, Toxicology and Mutagenesis Medicine Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Evaluation of Early Embryonic Loss Induced by Tributyltin Chloride in Rats: Phase- and Dose-Dependent Antifertility Effects

Tributyltin Chloride (TBTCl)-Enhanced Exopolysaccharide and Siderophore Production in an Estuarine Alcaligenes faecalis Strain

Effects of Silver Nanoparticle on Soil-Nitrification Processes

Subchronic Lead Feeding Study in Male Rats

Barium Toxicity Effects in Soybean Plants

Author’s Response

Effects of Subchronic Manganese Chloride Exposure on Tambaqui (Colossoma macropomum) Tissues: Oxidative Stress and Antioxidant Defenses

Effects of Organotin Alternative Antifoulants on Oyster Embryo

Endocrine-Disrupting Effects of Compounds in Danish Streams

Enhanced Inhibitory Effects of TBT Chloride on the Development of F1 Rats

Similar Documents

Evaluation of Early Embryonic Loss Induced by Tributyltin Chloride in Rats: Phase- and Dose-Dependent Antifertility Effects

Tributyltin Chloride (TBTCl)-Enhanced Exopolysaccharide and Siderophore Production in an Estuarine Alcaligenes faecalis Strain

Effects of Silver Nanoparticle on Soil-Nitrification Processes

Subchronic Lead Feeding Study in Male Rats

Barium Toxicity Effects in Soybean Plants

Author’s Response

Effects of Subchronic Manganese Chloride Exposure on Tambaqui (Colossoma macropomum) Tissues: Oxidative Stress and Antioxidant Defenses

Effects of Organotin Alternative Antifoulants on Oyster Embryo

Endocrine-Disrupting Effects of Compounds in Danish Streams

Enhanced Inhibitory Effects of TBT Chloride on the Development of F1 Rats