NDLI: Automated Solid Phase Extraction and Quantitative Measurement of 2,3-Dibromo-1-Propanol in Urine Using Gas Chromatography-Mass Spectrometry

Content Provider	Springer Nature Link
Author	Alwis, G. K. Hemakanthi Needham, Larry L. Barr, Dana B.
Copyright Year	2007
Abstract	2,3-Dibromo-1-propanol (DBP) was used as an active flame retardant in the 1970s. It was also used as an intermediate in the preparation of insecticide formulations, pharmaceuticals and the flame retardants tris(2,3-dibromopropyl) phosphate (Tris-BP) and tetrabromobisphenol A bis (2,3-dibromopropyl ether). DBP is also produced in vivo as a metabolic product of Tris-BP in humans. In 1977, sleepwear containing DBP and Tri-BP was banned because of evidence of carcinogenicity animal studies. Although the production of DBP was reduced after 1977, studies show that DBP is still detected in indoor air and dust; hence, the U.S. population may be exposed potentially to DBP. Only a few methods have been reported in the literature for assessing exposure to DBP or Tris-BP by measuring DBP in urine. These methods are based on a labor-intensive and time-consuming liquid-liquid extraction for the isolation of DBP from the urine matrix. To measure urinary DBP in humans, a fast, accurate, and sensitive method was developed with a limit of detection of 0.1 ng/mL and extraction recovery of 96%. This method involves enzymatic cleavage of the DBP-glucuronide or sulfate conjugate, automated solid phase extraction, and analysis by gas chromatography-mass spectrometry using 1,4-dibromo-2-butanol as the internal standard.
Starting Page	134
Ending Page	139
Page Count	6
File Format	PDF
ISSN	00904341
Journal	Archives of Environmental Contamination and Toxicology
Volume Number	53
Issue Number	1
e-ISSN	14320703
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-03-29
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Terrestrial Pollution Agriculture Ecology Forestry Environment Soil Science & Conservation
Content Type	Text
Resource Type	Article
Subject	Pollution Health, Toxicology and Mutagenesis Medicine Toxicology

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