NDLI: Joint Toxicity of Similarly and Dissimilarly Acting Chemicals to Daphnia magna at Different Response Levels

Content Provider	Springer Nature Link
Author	Meri García, Daniel Kusk, K. Ole Christensen, Erik R.
Copyright Year	2003
Abstract	The toxicity of two amines, nonylamine and decylamine, which have a narcotic effect on organisms, and ethylparathion (enzymatic inhibitor) on Daphnia magna has been studied when acting singly and in joint toxicity tests. This was done on the basis of an isobologram method where curves of constant response, i.e., isoboles are plotted vs. the concentrations of the two toxicants. The concentrations that immobilized 50, 10, and 0% of the test population in 48 h (IC50-48h, IC10-48h, and IC0-48h) were calculated. It is shown that nonylamine–decylamine mixtures follow a near concentration addition model of joint toxicity, while ethylparathion–decylamine mixtures follow a less than additive or near independent action model. The study was performed using three toxicity indices: additive index, sum of toxic units, and similarity parameter λ. An analysis of the similarity parameter λ is done to evaluate whether it has a constant value for IC50-48h, IC10-48h, and IC0-48h. The results suggest that it is quite probable that a constant value of λ can be used to characterize all response levels, as the isoboles corresponding to the average value of the similarity parameter fit within the 95% confidence intervals of toxicant concentrations at all response levels. The average value of λ is about 0.80 for the nonylamine–decylamine test and 0.30 for the ethylparathion–decylamine test.
Starting Page	289
Ending Page	296
Page Count	8
File Format	PDF
ISSN	00904341
Journal	Archives of Environmental Contamination and Toxicology
Volume Number	45
Issue Number	3
e-ISSN	14320703
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Pollution Health, Toxicology and Mutagenesis Medicine Toxicology

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