NDLI: A Comprehensive Analysis of Plausible Genotoxic Covariates Among Workers of a Polyvinyl Chloride Plant Exposed to Vinyl Chloride Monomer

Content Provider	Springer Nature Link
Author	Kumar, Alagamuthu Karthick Balachandar, Vellingiri Arun, Meyyazhagan Ahamed, Shafi Ahammed Khan Mustaq Kumar, Shanmugam Suresh Balamuralikrishnan, Balasubramanium Sankar, Kathannan Sasikala, Keshavarao
Copyright Year	2012
Abstract	The aim of this study was to assess the frequency of chromosomal aberrations—including chromatid type aberrations (CTAs), chromosomal type aberrations, micronucleus (MN) comet assay, and XRCC1 399 Arg/Gln polymorphism—in peripheral blood lymphocytes of workers occupationally exposed to vinyl chloride monomer (VCM). A total of 52 workers and an equal number of controls were recruited into the study to explore the potential cytogenetic risk of occupational exposure to VCM. Questionnaires were administered to obtain details of habitual cigarette-smoking, alcohol-consumption pattern, and occupation, etc. The exposed subjects and controls were classified into two groups based on age (group I <40 years; group II ≥40 years), and exposed subjects were further classified based on exposure duration (>8 and ≥8 years). CTA, MN, and comet assay frequency were significantly greater in polyvinyl chloride (PVC) factory workers (p < 0.05) with long-duration work. CTA, MN, and comet assay values were found to be increased with age in exposed subjects as well as in controls, with exposed subjects showing a statistically greater degree. An extensively greater MN frequency was observed in smokers exposed to VCM than in the control group (P < 0.05). The mean tail length of exposed subjects was greater compared with controls. The study on XRCC1 399 Arg/gln polymorphism in PVC factory workers showed less significant difference in allele frequency compared with controls. In conclusion, this results of work provides evidence for an apparent genotoxic effect associated with VCM exposure. Our results reinforce the greater sensitivity of cytogenetic assays for biomonitoring of occupationally exposed populations. Statistics indicate that workers exposed to VCM are at carcinogenic risk and should be monitored for long-term adverse effects from their exposure.
Starting Page	652
Ending Page	658
Page Count	7
File Format	PDF
ISSN	00904341
Journal	Archives of Environmental Contamination and Toxicology
Volume Number	64
Issue Number	4
e-ISSN	14320703
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-12-28
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ecotoxicology Pollution Environmental Health Environmental Chemistry Soil Science & Conservation Environmental Monitoring/Analysis
Content Type	Text
Resource Type	Article
Subject	Pollution Health, Toxicology and Mutagenesis Medicine Toxicology

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