NDLI: On Primordial Sense–Antisense Coding

Content Provider	Springer Nature Link
Author	Rodin, Andrei S. Rodin, Sergei N. Carter, Charles W.
Copyright Year	2009
Abstract	The genetic code is implemented by aminoacyl-tRNA synthetases (aaRS). These 20 enzymes are divided into two classes that, despite performing same functions, have nothing common in structure. The mystery of this striking partition of aaRSs might have been concealed in their sterically complementary modes of tRNA recognition that, as we have found recently, protect the tRNAs with complementary anticodons from confusion in translation. This finding implies that, in the beginning, life increased its coding repertoire by the pairs of complementary codons (rather than one-by-one) and used both complementary strands of genes as templates for translation. The class I and class II aaRSs may represent one of the most important examples of such primordial sense–antisense (SAS) coding (Rodin and Ohno, Orig Life Evol Biosph 25:565–589, 1995). In this report, we address the issue of SAS coding in a wider scope. We suggest a variety of advantages that such coding would have had in exploring a wider sequence space before translation became highly specific. In particular, we confirm that in Achlya klebsiana a single gene might have originally coded for an HSP70 chaperonin (class II aaRS homolog) and an NAD-specific GDH-like enzyme (class I aaRS homolog) via its sense and antisense strands. Thus, in contrast to the conclusions in Williams et al. (Mol Biol Evol 26:445–450, 2009), this could indeed be a “Rosetta stone” gene (Carter and Duax, Mol Cell 10:705–708, 2002) (eroded somewhat, though) for the SAS origin of the two aaRS classes.
Starting Page	555
Ending Page	567
Page Count	13
File Format	PDF
ISSN	00222844
Journal	Journal of Molecular Evolution
Volume Number	69
Issue Number	5
e-ISSN	14321432
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-12-03
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	RNA world Genetic code Sense–antisense coding Aminoacyl-tRNA synthetases NAD-GDH HSP70 Rosetta stone Animal Genetics and Genomics Plant Genetics & Genomics Plant Sciences Microbiology Evolutionary Biology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Ecology, Evolution, Behavior and Systematics

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