NDLI: The Origin of the 5S Ribosomal RNA Molecule Could Have Been Caused by a Single Inverse Duplication: Strong Evidence from Its Sequences

Content Provider	Springer Nature Link
Author	Branciamore, Sergio Di Giulio, Massimo
Copyright Year	2012
Abstract	The secondary structure of the 5S ribosomal RNA (5S rRNA) molecule shows a high degree of symmetry. In order to explain the origin of this symmetry, it has been conjectured that one half of the 5S rRNA molecule was its precursor and that an indirect duplication of this precursor created the other half and thus the current symmetry of the molecule. Here, we have subjected to an empirical test both the indirect duplication model, analysing a total of 684 5S rRNA sequences for complementarity between the two halves of the 5S rRNA, and the direct duplication model analysing in this case the similarity between the two halves of this molecule. In intra- and inter-molecule and intra- and inter-domain comparisons, we find a high statistical support to the hypothesis of a complementarity relationship between the two halves of the 5S rRNA molecule, denying vice versa the hypothesis of similarity between these halves. Therefore, these observations corroborate the indirect duplication model at the expense of the direct duplication model, as reason of the origin of the 5S rRNA molecule. More generally, we discuss and favour the hypothesis that all RNAs and proteins, which present symmetry, did so through gene duplication and not by gradualistic accumulation of few monomers or segments of molecule into a gradualistic growth process. This would be the consequence of the very high propensity that nucleic acids have to be subjected to duplications.
Starting Page	170
Ending Page	186
Page Count	17
File Format	PDF
ISSN	00222844
Journal	Journal of Molecular Evolution
Volume Number	74
Issue Number	3-4
e-ISSN	14321432
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-04-11
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Duplication models Indirect and direct duplications Gradualistic and punctuated evolution of molecules Symmetrical molecules Evolutionary precursors Animal Genetics and Genomics Cell Biology Microbiology Plant Sciences Plant Genetics & Genomics Evolutionary Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Ecology, Evolution, Behavior and Systematics

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