NDLI: Lineage-Specific Duplications of Muroidea Faim and Spag6 Genes and Atypical Accelerated Evolution of the Parental Spag6 Gene

Content Provider	Springer Nature Link
Author	Qiu, Huan Gołas, Aniela Grzmil, Paweł Wojwski, Leszek
Copyright Year	2013
Abstract	Gene duplications restricted to single lineage combined with an asymmetric evolution of the resulting genes may play particularly important roles in this lineage’s biology. We searched and identified asymmetrical evolution in nine gene families that duplicated exclusively in rodents and are present as single-copies in human, dog, cow, elephant, opossum, chicken, lizard, and Western clawed frog. Among those nine gene families are Fas apoptosis inhibitory molecule (Faim), implicated in apoptosis, and Sperm antigen 6 (Spag6), implicated in sperm mobility. Both genes were duplicated in or before the Muroidea ancestor. Due to the highly asymmetric evolution of the resulting paralogs, the existence of these duplications had been previously overlooked. Interestingly, Spag6, previously regarded and characterized as a single-copy ortholog of human Spag6, turns out to be a Muroidea-specific paralog. Conversely, the newly identified, highly divergent Spag6-BC061194 is in fact the parental gene. In consequence, this gene represents a rare exception from the general rule of rapid evolution of derived rather than parental genes following gene duplication. Unusual genes such as murine Spag6 may help to understand which mechanisms are responsible for this rule.
Starting Page	119
Ending Page	129
Page Count	11
File Format	PDF
ISSN	00222844
Journal	Journal of Molecular Evolution
Volume Number	77
Issue Number	3
e-ISSN	14321432
Language	English
Publisher	Springer US
Publisher Date	2013-09-27
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Gene duplication Asymmetric evolution Faim Spag6 Positive selection Evolutionary Biology Microbiology Plant Sciences Plant Genetics & Genomics Animal Genetics and Genomics Cell Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Ecology, Evolution, Behavior and Systematics

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