NDLI: Molecular Evolution of Viral Multifunctional Proteins: The Case of Potyvirus HC-Pro

Content Provider	Springer Nature Link
Author	Hasiów Jaroszewska, Beata Fares, Mario A. Elena, Santiago F.
Copyright Year	2013
Abstract	Our knowledge on the mode of evolution of the multifunctional viral proteins remains incomplete. To tackle this problem, here, we have investigated the evolutionary dynamics of the potyvirus multifunctional protein HC-Pro, with particular focus on its functional domains. The protein was partitioned into the three previously described functional domains, and each domain was analyzed separately and assembled. We searched for signatures of adaptive evolution and evolutionary dependencies of amino acid sites within and between the three domains using the entire set of available potyvirus sequences in GenBank. Interestingly, we identified strongly significant patterns of co-occurrence of adaptive events along the phylogenetic tree in the three domains. These patterns suggest that Domain I, whose main function is to mediate aphid transmission, has likely been coevolving with the other two domains, which are involved in different functions but all requiring the capacity to bind RNA. By contrast, episodes of positive selection on Domains II and III did not correlate, reflecting a trade-off between their evolvability and their evolutionary dependency likely resulting from their functional overlap. Covariation analyses have identified several groups of amino acids with evidence of concerted variation within each domain, but interdomain significant covariations were only found for Domains II and III, further reflecting their functional overlapping.
Starting Page	75
Ending Page	86
Page Count	12
File Format	PDF
ISSN	00222844
Journal	Journal of Molecular Evolution
Volume Number	78
Issue Number	1
e-ISSN	14321432
Language	English
Publisher	Springer US
Publisher Date	2013-11-23
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Multifunctional proteins Selective constraints Trade-offs Virus evolution Evolutionary Biology Microbiology Plant Sciences Plant Genetics & Genomics Animal Genetics and Genomics Cell Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Ecology, Evolution, Behavior and Systematics

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