NDLI: Gene Conversion Among Paralogs Results in Moderate False Detection of Positive Selection Using Likelihood Methods

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Gene Conversion Among Paralogs Results in Moderate False Detection of Positive Selection Using Likelihood Methods

Content Provider	Springer Nature Link
Author	Casola, Claudio Hahn, Matthew W.
Copyright Year	2009
Abstract	Previous studies have shown that recombination between allelic sequences can cause likelihood-based methods for detecting positive selection to produce many false-positive results. In this article, we use simulations to study the impact of nonallelic gene conversion on the specificity of PAML to detect positive selection among gene duplicates. Our results show that, as expected, gene conversion leads to higher rates of false-positive results, although only moderately. These rates increase with the genetic distance between sequences, the length of converted tracts, and when no outgroup sequences are included in the analysis. We also find that branch-site models will incorrectly identify unconverted sequences as the targets of positive selection when their close paralogs are converted. Bayesian prediction of sites undergoing adaptive evolution implemented in PAML is affected by conversion, albeit in a less straightforward way. Our work suggests that particular attention should be devoted to the evolutionary analysis of recent duplicates that may have experienced gene conversion because they may provide false signals of positive selection. Fortunately, these results also imply that those cases most susceptible to false-positive results—i.e., high divergence between paralogs, long conversion tracts—are also the cases where detecting gene conversion is the easiest.
Starting Page	679
Ending Page	687
Page Count	9
File Format	PDF
ISSN	00222844
Journal	Journal of Molecular Evolution
Volume Number	68
Issue Number	6
e-ISSN	14321432
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-05-27
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Recombination Adaptive evolution Gene duplicates PAML Animal Genetics and Genomics Plant Genetics & Genomics Plant Sciences Microbiology Evolutionary Biology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Ecology, Evolution, Behavior and Systematics

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