NDLI: Influence of genetic polymorphisms in cytochrome P450 oxidoreductase on the variability in stable warfarin maintenance dose in Han Chinese

Please wait, while we are loading the content...

Prediction of drug interaction between oral adsorbent AST-120 and concomitant drugs based on the in vitro dissolution and in vivo absorption behavior of the drugs

Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction

Evaluation of the pharmacokinetics of glibenclamide tablet given, off label, orally to children suffering from neonatal syndromic hyperglycemia

Adherence to antidepressants among women and men described with trajectory models: a Swedish longitudinal study

High prevalence of potential drug-drug interactions in patients with castration-resistant prostate cancer treated with abiraterone acetate

Quantifying behavioural determinants relating to health professional reporting of medication errors: a cross-sectional survey using the Theoretical Domains Framework

Tocilizumab and mesenteric arterial thrombosis: drug-drug interaction with anticoagulants metabolized by CYP 450 and/or by P-glycoprotein

Cetrimide-induced oral mucositis: an unusual adverse drug reaction

European Journal of Clinical Pharmacology : Volume 72, Issue 10, October 2016

European Journal of Clinical Pharmacology : Volume 72, Issue 9, September 2016

European Journal of Clinical Pharmacology : Volume 72, Issue 7, July 2016

European Journal of Clinical Pharmacology : Volume 72, Issue 6, June 2016

European Journal of Clinical Pharmacology : Volume 72, Issue 2, February 2016

European Journal of Clinical Pharmacology : Volume 67

European Journal of Clinical Pharmacology : Volume 62

European Journal of Clinical Pharmacology : Volume 57

Influence of genetic polymorphisms in cytochrome P450 oxidoreductase on the variability in stable warfarin maintenance dose in Han Chinese

Content Provider	Springer Nature Link
Author	Zeng, Wu Tao Xu, Qing Li, Cheng Hsun Chen, Wei Yan Sun, Xiu Ting Wang, Xiang Yang, Yi Ying Shi, Hui Yang, Zhi Sheng
Copyright Year	2016
Abstract	The aim of this study was to investigate whether any of the single-nucleotide polymorphisms (SNPs) in the POR gene were significantly associated with CYP activity and expression, and could contribute to the total variability in stable warfarin maintenance doses in Han Chinese.A total of 408 patients treated at the First Affiliated Hospital of Sun Yat-Sen University were eligible for the study and had attained a stable warfarin maintenance dose at the start of the investigation. Demographics, warfarin maintenance doses, and concomitant medications were documented. Genomic DNA was extracted from peripheral blood samples and genotyped for ten SNPs (CYP 2C92 and 3, CYP4F2 rs2108622, VKORC1 −1639C>T, and potential POR genes of rs10239977, rs3815455, rs41301394, rs56256515, rs1057868, and rs2286823) using the Sequenom MassARRAY genotyping system.A predictive model of warfarin maintenance dose was established and indicated that age, gender, body surface area, aspirin use, CYP2C93, CYP4F2 rs2108622, VKORC1 −1639C>T, and POR37 831–35C>T accounted for 42.4 % of dose variance in patients undergoing anticoagulant treatment. The contribution of POR37 831–35C>T to warfarin dose variation was only 3.9 %.For the first time, the SNP POR37 831–35C>T was confirmed as a minor but statistically significant factor associated with interindividual variation in warfarin maintenance dose in Han Chinese. The POR*37 gene polymorphism should be considered in future algorithms for faster and more reliable achievement of stable warfarin maintenance doses.
Starting Page	1327
Ending Page	1334
Page Count	8
File Format	PDF
ISSN	00316970
Journal	European Journal of Clinical Pharmacology
Volume Number	72
Issue Number	11
e-ISSN	14321041
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-08-04
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Warfarin Gene polymorphism POR Predictive formula of maintenance dose Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The P450 oxidoreductase (POR) rs2868177 and cytochrome P450 (CYP) 2B6*6 polymorphisms contribute to the interindividual variability in human CYP2B6 activity

Effects of VKORC1 Genetic Polymorphisms on Warfarin Maintenance Dose Requirement in a Chinese Han Population.

Evaluation of genetic factors for warfarin dose prediction (2006).

Functional Characterization of Human CYP2C9 Allelic Variants in COS-7 Cells

Genetic Polymorphisms and Haplotypes of POR, Encoding Cytochrome P450 Oxidoreductase, in a Japanese Population

Effects of VKORC1 Genetic Polymorphisms on Warfarin Maintenance Dose Requirement in a Chinese Han Population

Identification of cytochrome P450 oxidoreductase gene variants that are significantly associated with the interindividual variations in warfarin maintenance dose.

Pharmacogenetic-Guided Algorithm to Improve Daily Dose of Warfarin in Elder Han-Chinese Population

Polymorphisms of VKORC1 and CYP2C9 are associated with warfarin sensitivity in Chinese population

Influence of genetic polymorphisms in cytochrome P450 oxidoreductase on the variability in stable warfarin maintenance dose in Han Chinese

Similar Documents

The P450 oxidoreductase (POR) rs2868177 and cytochrome P450 (CYP) 2B6*6 polymorphisms contribute to the interindividual variability in human CYP2B6 activity

Effects of VKORC1 Genetic Polymorphisms on Warfarin Maintenance Dose Requirement in a Chinese Han Population.

Evaluation of genetic factors for warfarin dose prediction (2006).

Functional Characterization of Human CYP2C9 Allelic Variants in COS-7 Cells

Genetic Polymorphisms and Haplotypes of POR, Encoding Cytochrome P450 Oxidoreductase, in a Japanese Population

Effects of VKORC1 Genetic Polymorphisms on Warfarin Maintenance Dose Requirement in a Chinese Han Population

Identification of cytochrome P450 oxidoreductase gene variants that are significantly associated with the interindividual variations in warfarin maintenance dose.

Pharmacogenetic-Guided Algorithm to Improve Daily Dose of Warfarin in Elder Han-Chinese Population

Polymorphisms of VKORC1 and CYP2C9 are associated with warfarin sensitivity in Chinese population

Influence of genetic polymorphisms in cytochrome P450 oxidoreductase on the variability in stable warfarin maintenance dose in Han Chinese