NDLI: Changes in utilisation of antiepileptic drugs in epilepsy and non-epilepsy disorders—a pharmacoepidemiological study and clinical implications

Please wait, while we are loading the content...

Impact of genetic polymorphisms related to clopidogrel or acetylsalicylic acid pharmacology on clinical outcome in Chinese patients with symptomatic extracranial or intracranial stenosis

The P450 oxidoreductase (POR) rs2868177 and cytochrome P450 (CYP) 2B6*6 polymorphisms contribute to the interindividual variability in human CYP2B6 activity

Serotonin transporter gene (SLC6A4) polymorphisms are associated with response to fluoxetine in south Indian major depressive disorder patients

Levobupivacaine absorption pharmacokinetics with and without epinephrine during TAP block: analysis of doses based on the associated risk of local anaesthetic toxicity

Evaluating patients’ comprehensibility of a standardized medication plan

Ibuprofen-associated hypothermia in children: analysis of the Italian spontaneous reporting database

Changes in utilisation of antiepileptic drugs in epilepsy and non-epilepsy disorders—a pharmacoepidemiological study and clinical implications

Effect of prehospital epinephrine on out-of-hospital cardiac arrest: a report from the national out-of-hospital cardiac arrest data registry in Japan, 2011–2012

Use of cardioselective β-blockers and overall death and cardiovascular outcomes in patients with COPD: a population-based cohort study

Do the EMA accelerated assessment procedure and the FDA priority review ensure a therapeutic added value? 2006–2015: a cohort study

Prevention of selective outcome reporting: let us start from the beginning

European Journal of Clinical Pharmacology : Volume 72, Issue 9, September 2016

European Journal of Clinical Pharmacology : Volume 72, Issue 7, July 2016

European Journal of Clinical Pharmacology : Volume 72, Issue 6, June 2016

European Journal of Clinical Pharmacology : Volume 72, Issue 2, February 2016

European Journal of Clinical Pharmacology : Volume 67

European Journal of Clinical Pharmacology : Volume 62

European Journal of Clinical Pharmacology : Volume 57

Changes in utilisation of antiepileptic drugs in epilepsy and non-epilepsy disorders—a pharmacoepidemiological study and clinical implications

Content Provider	Springer Nature Link
Author	Baftiu, Arton Johannessen Landmark, Cecilie Rusten, Ida Rudberg Feet, Silje Andrea Johannessen, Svein I. Larsson, Pål G.
Copyright Year	2016
Abstract	The purpose of this study was to investigate changes in utilisation of antiepileptic drugs (AEDs) in epilepsy and non-epilepsy disorders in Norway and furthermore to study the retention rates of the most commonly used AEDs in these indications in long-term use.The data consisted of all prescriptions of AEDs from Norwegian pharmacies in the Norwegian Prescription Database (NorPD) (2004–2012). Variables included anonymous data regarding age, gender, diagnosis specific reimbursement codes and utilisation of AEDs.In recent years (2008–2012), the utilisation of AEDs in non-epilepsy disorders accounted for 45–53 % of the total use. In epilepsy, the most commonly used AED was lamotrigine, followed by levetiracetam, carbamazepine and valproate. Lamotrigine was also the predominant AED used in psychiatry, while pregabalin and gabapentin were mostly used in neuropathic pain. In migraine, topiramate predominated but accounted for <1 % of the total utilisation of AEDs. The majority of prescriptions were by general practitioners and only 20 % by specialists. Regardless of indication, newer AEDs had higher retention rates (34–48 %) and were used for a longer period before discontinuation.The use of AEDs in non-epilepsy disorders is increasing and accounted for 53 % in 2012. Newer AEDs were predominantly used and demonstrated higher retention rates than older AEDs in all indications. This nationwide study demonstrates an increased exposure to AEDs in new patient groups, and details in prescription patterns and clinical and safety considerations should be closely monitored. This contributes to long-term post-marketing data of AED and accordingly improved pharmacovigilance.
Starting Page	1245
Ending Page	1254
Page Count	10
File Format	PDF
ISSN	00316970
Journal	European Journal of Clinical Pharmacology
Volume Number	72
Issue Number	10
e-ISSN	14321041
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-07-13
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Antiepileptic drugs Epilepsy Non-epilepsy indications Norwegian Prescription Database (NorPD) Retention rates Pharmacoepidemiology Pharmacovigilance Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Erratum to: Changes in utilisation of antiepileptic drugs in epilepsy and non-epilepsy disorders—A pharmacoepidemiological study and clinical implications

Prescription of Drugs to Pregnant Women in France: the HIMAGE Study

Risk of antidepressant initiation among users of cardiovascular agents and metformin. Findings from the Trøndelag Health Study (HUNT) and Norwegian Prescription Database (NorPD), Norway: Findings from the Trøndelag Health Study (HUNT) and Norwegian Prescription Database (NorPD), Norway.

Antiepileptic drug use in Italian children over a decade

Prioritizing children's medicines for research: a pharmacoepidemiological study of antiepileptic drugs

Prescription of drugs during pregnancy: a study using EFEMERIS, the new French database

Use of Antiepileptic Drugs During Pregnancy: Evolving Concepts

Establishment of the nationwide Norwegian Prescription Database (NorPD)—new opportunities for research

Clinical development of antiepileptic drugs for children

Changes in utilisation of antiepileptic drugs in epilepsy and non-epilepsy disorders—a pharmacoepidemiological study and clinical implications

Similar Documents

Erratum to: Changes in utilisation of antiepileptic drugs in epilepsy and non-epilepsy disorders—A pharmacoepidemiological study and clinical implications

Prescription of Drugs to Pregnant Women in France: the HIMAGE Study

Risk of antidepressant initiation among users of cardiovascular agents and metformin. Findings from the Trøndelag Health Study (HUNT) and Norwegian Prescription Database (NorPD), Norway: Findings from the Trøndelag Health Study (HUNT) and Norwegian Prescription Database (NorPD), Norway.

Antiepileptic drug use in Italian children over a decade

Prioritizing children's medicines for research: a pharmacoepidemiological study of antiepileptic drugs

Prescription of drugs during pregnancy: a study using EFEMERIS, the new French database

Use of Antiepileptic Drugs During Pregnancy: Evolving Concepts

Establishment of the nationwide Norwegian Prescription Database (NorPD)—new opportunities for research

Clinical development of antiepileptic drugs for children

Changes in utilisation of antiepileptic drugs in epilepsy and non-epilepsy disorders—a pharmacoepidemiological study and clinical implications