NDLI: Resveratrol treatment improves plasma and blood glucose concentration and lipid metabolism in high-fat-fed C57BL/6J mice

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Resveratrol treatment improves plasma and blood glucose concentration and lipid metabolism in high-fat-fed C57BL/6J mice

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European Food Research and Technology : Volume 242, Issue 10, October 2016

European Food Research and Technology : Volume 242, Issue 9, September 2016

European Food Research and Technology : Volume 242, Issue 8, August 2016

European Food Research and Technology : Volume 242, Issue 7, July 2016

European Food Research and Technology : Volume 224

Resveratrol treatment improves plasma and blood glucose concentration and lipid metabolism in high-fat-fed C57BL/6J mice

Content Provider	Springer Nature Link
Author	Yu, Yue Zhang, Ning Jiang, Heng Xue, Wei Guo, Xinhui Xu, Xiaoling Fang, Weichun Wang, Hao Hua, Erbing
Copyright Year	2016
Abstract	SIRT1 is the homologue of SIR2 that links to longevity in lower organisms and has a direct or indirect role that positively regulates the metabolic pathway via insulin signaling. RSV, a naturally occurring small polyphenol that activates SIRT1, has been reported to ameliorate the early development of metabolic syndrome of high-fat-diet-fed mice at a low dose (0.005 w/w) in 10 weeks through inhibition of fatty acid synthase and other relevant enzymes. However, what effect of a higher dose of dietary RSV on the long-term high-fat-diet-fed C57BL/6J mice has not been reported in view of regulating SIRT1 and related genes. This study investigated the effect of a higher dose of RSV (0.1 % w/w) on glucose and lipid metabolism in 13-week high-fat-diet-fed C57BL/6J mice as well as on mRNA and protein expression regulations with respect to relevant genes. The data showed that a higher dose of RSV supplementation significantly lowered the concentration of glucose, plasma total cholesterol, total triglyceride concentrations, and hepatic cholesterol in high-fat-diet-fed mice. Relative mRNA expressions of SIRT1, FOXO1, PPARγ, and PGC-1α were significantly up-regulated, and corresponding protein expressions were also enhanced.
Starting Page	1849
Ending Page	1856
Page Count	8
File Format	PDF
ISSN	14382377
Journal	European Food Research and Technology
Volume Number	242
Issue Number	11
e-ISSN	14382385
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-05-04
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Resveratrol SIRT1 Genetic regulation Activation Food Science Analytical Chemistry Biotechnology Agriculture Forestry
Content Type	Text
Resource Type	Article
Subject	Industrial and Manufacturing Engineering Chemistry Biochemistry Food Science Biotechnology

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