NDLI: Behavioral alterations of zebrafish larvae after early embryonic exposure to ketamine

Content Provider	Springer Nature Link
Author	Félix, Luís M. Antunes, Luís M. Coimbra, Ana M. Valentim, Ana M.
Copyright Year	2016
Abstract	Ketamine has been associated with pediatric risks that include neurocognitive impairment and long-term behavioral disorders. However, the neurobehavioral effects of ketamine exposure in early development remain uncertain.This study aimed to test stage- and dose-dependent effects of ketamine exposure on certain brain functions by evaluating alterations in locomotion, anxiety-like and avoidance behaviors, as well as socialization.Embryos were exposed to different concentrations of ketamine (0, 0.2, 0.4, and 0.8 mg mL−1) for 20 min during the 256-cell (2.5 h post fertilization—hpf), 50% epiboly (5.5 hpf), and 1–4 somites (10.5 hpf) stages. General exploratory activities, natural escape-like responses, and social interactions were analyzed under continuous light or under a moving light stimulus.A dose-dependent decrease in the overall mean speed was perceived in the embryos exposed during the 256-cell stage. These results were related to previously observed head and eye malformations, following ketamine exposure at this stage and may indicate possible neurobehavioral disorders when ketamine exposure is performed at this stage. Results also showed that ketamine exposure during the 50% epiboly and 1–4 somites stages induced a significant increment of the anxiety-like behavior and a decrease in avoidance behavior in all exposed groups.Overall, the results validate the neurodevelopmental risks of early-life exposure to ketamine.
Starting Page	549
Ending Page	558
Page Count	10
File Format	PDF
ISSN	00333158
Journal	Psychopharmacology
Volume Number	234
Issue Number	4
e-ISSN	14322072
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-12-08
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Zebrafish larvae Developmental stages Locomotion Ketamine Anxiety-like behaviors Avoidance response Neurosciences Pharmacology/Toxicology Psychiatry
Content Type	Text
Resource Type	Article
Subject	Pharmacology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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